Increased Soluble CMG2 Serum Protein Concentration Is Associated with the Progression of Prostate Carcinoma
Prostate carcinoma (PCa) is one of the leading causes of cancer-related death in males, but biomarkers for the prognosis are rare. Capillary morphogenesis gene 2 (CMG2) is a modulator of extracellular matrix remodeling during angiogenesis. Four isoforms of CMG2 have been described so far, one secret...
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doaj-6ffa4fcd7ad64a16b7833bed92574b722020-11-25T01:57:01ZengMDPI AGCancers2072-66942019-07-01118105910.3390/cancers11081059cancers11081059Increased Soluble CMG2 Serum Protein Concentration Is Associated with the Progression of Prostate CarcinomaThomas Greither0Marios Marcou1Paolo Fornara2Hermann M. Behre3Center for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), GermanyCenter for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), GermanyClinics for Urology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), GermanyCenter for Reproductive Medicine and Andrology, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), GermanyProstate carcinoma (PCa) is one of the leading causes of cancer-related death in males, but biomarkers for the prognosis are rare. Capillary morphogenesis gene 2 (CMG2) is a modulator of extracellular matrix remodeling during angiogenesis. Four isoforms of CMG2 have been described so far, one secreted in the serum as soluble CMG2 (sCMG2). The aim of this study was to evaluate the sCMG2 serum concentrations in 179 PCa patients and 163 age-matched control subjects by ELISA and correlate it to clinical and demographic parameters. We observed that sCMG2 concentration is increased in the serum of PCa patients with metastases, while no significant differences in the concentrations were detected between the control subjects and patients with localized PCa. Furthermore, elevated sCMG2 concentrations were significantly associated with the highest T stage. Increased sCMG2 serum concentrations tended to be associated with a worsened overall and disease-specific survival of the PCa patients. In conclusion, sCMG2 may be an interesting additive biomarker for the prediction of the progression of PCa and the patients’ outcome.https://www.mdpi.com/2072-6694/11/8/1059prostate cancerprognosisserum biomarkerCMG2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas Greither Marios Marcou Paolo Fornara Hermann M. Behre |
spellingShingle |
Thomas Greither Marios Marcou Paolo Fornara Hermann M. Behre Increased Soluble CMG2 Serum Protein Concentration Is Associated with the Progression of Prostate Carcinoma Cancers prostate cancer prognosis serum biomarker CMG2 |
author_facet |
Thomas Greither Marios Marcou Paolo Fornara Hermann M. Behre |
author_sort |
Thomas Greither |
title |
Increased Soluble CMG2 Serum Protein Concentration Is Associated with the Progression of Prostate Carcinoma |
title_short |
Increased Soluble CMG2 Serum Protein Concentration Is Associated with the Progression of Prostate Carcinoma |
title_full |
Increased Soluble CMG2 Serum Protein Concentration Is Associated with the Progression of Prostate Carcinoma |
title_fullStr |
Increased Soluble CMG2 Serum Protein Concentration Is Associated with the Progression of Prostate Carcinoma |
title_full_unstemmed |
Increased Soluble CMG2 Serum Protein Concentration Is Associated with the Progression of Prostate Carcinoma |
title_sort |
increased soluble cmg2 serum protein concentration is associated with the progression of prostate carcinoma |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2019-07-01 |
description |
Prostate carcinoma (PCa) is one of the leading causes of cancer-related death in males, but biomarkers for the prognosis are rare. Capillary morphogenesis gene 2 (CMG2) is a modulator of extracellular matrix remodeling during angiogenesis. Four isoforms of CMG2 have been described so far, one secreted in the serum as soluble CMG2 (sCMG2). The aim of this study was to evaluate the sCMG2 serum concentrations in 179 PCa patients and 163 age-matched control subjects by ELISA and correlate it to clinical and demographic parameters. We observed that sCMG2 concentration is increased in the serum of PCa patients with metastases, while no significant differences in the concentrations were detected between the control subjects and patients with localized PCa. Furthermore, elevated sCMG2 concentrations were significantly associated with the highest T stage. Increased sCMG2 serum concentrations tended to be associated with a worsened overall and disease-specific survival of the PCa patients. In conclusion, sCMG2 may be an interesting additive biomarker for the prediction of the progression of PCa and the patients’ outcome. |
topic |
prostate cancer prognosis serum biomarker CMG2 |
url |
https://www.mdpi.com/2072-6694/11/8/1059 |
work_keys_str_mv |
AT thomasgreither increasedsolublecmg2serumproteinconcentrationisassociatedwiththeprogressionofprostatecarcinoma AT mariosmarcou increasedsolublecmg2serumproteinconcentrationisassociatedwiththeprogressionofprostatecarcinoma AT paolofornara increasedsolublecmg2serumproteinconcentrationisassociatedwiththeprogressionofprostatecarcinoma AT hermannmbehre increasedsolublecmg2serumproteinconcentrationisassociatedwiththeprogressionofprostatecarcinoma |
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1724977031077167104 |