Cardiac conduction defects and Brugada syndrome: A family with overlap syndrome carrying a nonsense SCN5A mutation

Cardiac conduction defects and Brugada syndrome: A family with overlap syndrome carrying a nonsense SCN5A mutation

Background: Phenotypes often differ even within family members carrying the same SCN5A mutation. We aimed to evaluate the genetic modifiers in a family with Brugada syndrome (BrS) and sick sinus syndrome (SSS) with an SCN5A mutation that causes the truncated alpha-subunit of cardiac Na channel prote...

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Bibliographic Details
Main Authors: Hisaaki Aoki, MD, PHD, Yoshihide Nakamura, MD, Seiko Ohno, MD, PHD, Takeru Makiyama, MD, PHD, Minoru Horie, MD, PHD
Format: Article
Language:English
Published: Wiley 2017-02-01
Series:Journal of Arrhythmia
Subjects:
SCN5A
Overlap syndrome
Children
Pilsicainide challenge test
Online Access:http://www.sciencedirect.com/science/article/pii/S1880427616300655

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