Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative
Reducing aerobic ethanol production, a phenomenon referred to as the Crabtree effect, may open up new perspectives for using yeast as a cell factory. Here, the authors turn the Crabtree-positive yeast into Crabtree negative by combined engineering of cytosolic acetyl-CoA metabolism and mutating the...
Main Authors: | Zongjie Dai, Mingtao Huang, Yun Chen, Verena Siewers, Jens Nielsen |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-05409-9 |
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