Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function

Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function

Infantile-onset Neuronal Ceroid Lipofuscinosis (INCL) is a severe pediatric neurodegenerative disorder produced by mutations in the gene encoding palmitoyl-protein thioesterase 1 (Ppt1). This enzyme is responsible for the removal of a palmitate post-translational modification from an unknown set of...

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Bibliographic Details
Main Authors: Stephanie Saja, Haley Buff, Alexis C. Smith, Tiffany S. Williams, Christopher A. Korey
Format: Article
Language:English
Published: Elsevier 2010-10-01
Series:Neurobiology of Disease
Subjects:
Neuronal Ceroid Lipofuscinosis
Batten Disease
Palmitoylation
Palmitoyl-protein thioesterase 1
Trafficking
Endocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000574

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