Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity
Abstract Background Metabolic perturbations and slower renewal of cellular components associated with aging increase the risk of Parkinson’s disease (PD). Declining activity of AMPK, a critical cellular energy sensor, may therefore contribute to neurodegeneration. Methods Here, we overexpress variou...
Main Authors: | Wojciech Bobela, Sameer Nazeeruddin, Graham Knott, Patrick Aebischer, Bernard L. Schneider |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2017-11-01
|
Series: | Molecular Neurodegeneration |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13024-017-0220-x |
Similar Items
-
Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson’s Disease
by: Wojciech Bobela, et al.
Published: (2015-10-01) -
The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro
by: Marija Dulovic, et al.
Published: (2014-03-01) -
Neuroprotective Treatments in Parkinson’s Disease
by: Elif, et al.
Published: (2019-12-01) -
Neuroprotective function of Omi to α-synuclein-induced neurotoxicity
by: Hea-Jong Chung, et al.
Published: (2020-03-01) -
Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models
by: Hayate Javed, et al.
Published: (2019-03-01)