A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.
shRNA expression is an established technique to transiently or permanently deplete cells of a particular mRNA/protein. In functional analyses of oncogenic pathways it can thus be used as an alternative to pharmacologic inhibitors, or as a means to address otherwise undruggable targets. Here we descr...
Main Authors: | Severin Fink, Laurens Zugelder, Bernhard Roth, Evelyn Brandt, Sylvain Meloche, Zsuzsanna Izsvák, Ralf C Bargou, Thorsten Stühmer |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC6195277?pdf=render |
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