Gαi Signaling Promotes Marginal Zone B Cell Development by Enabling Transitional B Cell ADAM10 Expression

Gαi Signaling Promotes Marginal Zone B Cell Development by Enabling Transitional B Cell ADAM10 Expression

The follicular (FO) versus marginal zone (MZ) B cell fate decision in the spleen depends upon BCR, BAFF, and Notch2 signaling. Whether or how Gi signaling affects this fate decision is unknown. Here, we show that direct contact with Notch ligand expressing stromal cells (OP9-Delta-like 1) cannot pro...

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Bibliographic Details
Main Authors: Il-Young Hwang, Cedric Boularan, Kathleen Harrison, John H. Kehrl
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
heterotrimeric G-protein
Notch2
ADAM10
B lymphocyte
marginal zone
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00687/full

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