Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals
Abstract We aimed to evaluate factors associated with changes in skeletal muscle mass in hepatitis C virus (HCV)-infected patients after treatment with direct-acting antivirals (DAAs). Consecutive HCV-infected patients after treatment with DAA were recruited into the study. Patients who achieved sus...
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Language: | English |
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Nature Publishing Group
2021-08-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-96203-z |
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doaj-703302c7229a498a89aac76fc46f3e58 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoshimasa Tokuchi Goki Suda Megumi Kimura Osamu Maehara Takashi Kitagataya Akinori Kubo Sonoe Yoshida Qingjie Fu Zijian Yang Shunichi Hosoda Masatsugu Ohara Ren Yamada Kazuharu Suzuki Naoki Kawagishi Masato Nakai Takuya Sho Mitsuteru Natsuizaka Kenichi Morikawa Koji Ogawa Shunsuke Ohnishi Naoya Sakamoto |
spellingShingle |
Yoshimasa Tokuchi Goki Suda Megumi Kimura Osamu Maehara Takashi Kitagataya Akinori Kubo Sonoe Yoshida Qingjie Fu Zijian Yang Shunichi Hosoda Masatsugu Ohara Ren Yamada Kazuharu Suzuki Naoki Kawagishi Masato Nakai Takuya Sho Mitsuteru Natsuizaka Kenichi Morikawa Koji Ogawa Shunsuke Ohnishi Naoya Sakamoto Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals Scientific Reports |
author_facet |
Yoshimasa Tokuchi Goki Suda Megumi Kimura Osamu Maehara Takashi Kitagataya Akinori Kubo Sonoe Yoshida Qingjie Fu Zijian Yang Shunichi Hosoda Masatsugu Ohara Ren Yamada Kazuharu Suzuki Naoki Kawagishi Masato Nakai Takuya Sho Mitsuteru Natsuizaka Kenichi Morikawa Koji Ogawa Shunsuke Ohnishi Naoya Sakamoto |
author_sort |
Yoshimasa Tokuchi |
title |
Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals |
title_short |
Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals |
title_full |
Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals |
title_fullStr |
Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals |
title_full_unstemmed |
Possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antivirals |
title_sort |
possible correlation between increased serum free carnitine levels and increased skeletal muscle mass following hcv eradication by direct acting antivirals |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-08-01 |
description |
Abstract We aimed to evaluate factors associated with changes in skeletal muscle mass in hepatitis C virus (HCV)-infected patients after treatment with direct-acting antivirals (DAAs). Consecutive HCV-infected patients after treatment with DAA were recruited into the study. Patients who achieved sustained virological response (SVR); and had complete clinical information, preserved serum samples at baseline and SVR48, and skeletal muscle mass evaluations based on the psoas muscle mass index (PMI) on computed tomography at baseline and ≥ 12 months were included. Altogether, 70.7% of patients (41/58) showed increased PMI after DAA therapy, and mean relative PMI was significantly higher after DAA therapy than at baseline. There were no significant associations between baseline clinical factors routinely examined in clinical practice and increased PMI. Among factors reported to be associated with skeletal muscle loss in patients with chronic liver disease, serum zinc levels and total and free carnitine levels increased significantly after DAA therapy and only changes in serum free carnitine levels were significantly associated with an increased PMI (r = 0305, P = 0.020). In conclusion, increased skeletal muscle mass after successful HCV eradication by DAAs was significantly associated with increased serum-free carnitine levels. l-carnitine supplementation may be beneficial in patients with low skeletal muscle mass after DAA. |
url |
https://doi.org/10.1038/s41598-021-96203-z |
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doaj-703302c7229a498a89aac76fc46f3e582021-08-22T11:26:26ZengNature Publishing GroupScientific Reports2045-23222021-08-011111910.1038/s41598-021-96203-zPossible correlation between increased serum free carnitine levels and increased skeletal muscle mass following HCV eradication by direct acting antiviralsYoshimasa Tokuchi0Goki Suda1Megumi Kimura2Osamu Maehara3Takashi Kitagataya4Akinori Kubo5Sonoe Yoshida6Qingjie Fu7Zijian Yang8Shunichi Hosoda9Masatsugu Ohara10Ren Yamada11Kazuharu Suzuki12Naoki Kawagishi13Masato Nakai14Takuya Sho15Mitsuteru Natsuizaka16Kenichi Morikawa17Koji Ogawa18Shunsuke Ohnishi19Naoya Sakamoto20Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido UniversityDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineDepartment of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido UniversityDepartment of Gastroenterology and Hepatology, Hokkaido University Graduate School of MedicineAbstract We aimed to evaluate factors associated with changes in skeletal muscle mass in hepatitis C virus (HCV)-infected patients after treatment with direct-acting antivirals (DAAs). Consecutive HCV-infected patients after treatment with DAA were recruited into the study. Patients who achieved sustained virological response (SVR); and had complete clinical information, preserved serum samples at baseline and SVR48, and skeletal muscle mass evaluations based on the psoas muscle mass index (PMI) on computed tomography at baseline and ≥ 12 months were included. Altogether, 70.7% of patients (41/58) showed increased PMI after DAA therapy, and mean relative PMI was significantly higher after DAA therapy than at baseline. There were no significant associations between baseline clinical factors routinely examined in clinical practice and increased PMI. Among factors reported to be associated with skeletal muscle loss in patients with chronic liver disease, serum zinc levels and total and free carnitine levels increased significantly after DAA therapy and only changes in serum free carnitine levels were significantly associated with an increased PMI (r = 0305, P = 0.020). In conclusion, increased skeletal muscle mass after successful HCV eradication by DAAs was significantly associated with increased serum-free carnitine levels. l-carnitine supplementation may be beneficial in patients with low skeletal muscle mass after DAA.https://doi.org/10.1038/s41598-021-96203-z |