Adipose-Derived Stem Cells Primed with Paclitaxel Inhibit Ovarian Cancer Spheroid Growth and Overcome Paclitaxel Resistance

Adipose-Derived Stem Cells Primed with Paclitaxel Inhibit Ovarian Cancer Spheroid Growth and Overcome Paclitaxel Resistance

Adipose-derived stem cells (ADSCs) primed with paclitaxel (PTX) are now hypothesized to represent a potential Trojan horse to vehicle and deliver PTX into tumors. We analyzed the anticancer activity of PTX released by ADSCs primed with PTX (PTX-ADSCs) (~20 ng/mL) in a panel of ovarian cancer (OvCa)...

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Bibliographic Details
Main Authors: Cinzia Borghese, Naike Casagrande, Giuseppe Corona, Donatella Aldinucci
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Pharmaceutics
Subjects:
adipose-derived stem cells
ovarian cancer spheroids
anticancer chemotherapy
drug delivery
paclitaxel resistance
Online Access:https://www.mdpi.com/1999-4923/12/5/401

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