| Summary: | Abstract Background Three-dimensional printing (3DP) is an emerging technology used to describe 3D products manufactured on a digital design platform and in a layer by layer fashion. 3D printing technology has appeared as a major technological revolution of the recent years leading to the manufacturing and production of novel medical products and devices in pharmaceutical industry. The new technology has gained considerable attraction when the first commercial 3D tablet Spiratam® (levetiracetam) was approved by FDA in August 2015. Main text The key aspect of printing technology in the field of drug delivery is its versatility to create potential novel oral dosage forms. It also enables rapid, safe, and low-cost development in the production process which consequently leads to wide applications of this new technology in pharmaceutical fields. 3D printing also enhances patient convenience to further improve the medication compliance. Among various technical trends for fabricating 3D objects, extrusion-based printing, powder-based binding, and inject printing methods are of particular interest to the pharmaceutical industry which are discussed briefly in this paper. This study also provides different applications of 3D printing technology and highlights the impact of 3D printing as an innovative promising technology through presenting some examples as experimental studies in the fabrication of oral drug delivery systems. Conclusions Through reviewing some experimental studies, this mini review has shown that 3D printing technique can be successfully used on a small scale to produce tailored doses of drug products and has great advantages experimentally in the production of oral doses forms. Concerning the future of 3D printing, the new technology is likely to focus on production in hospitals and pharmacies for individuals or niche groups with specific needs. 3D printing may also offer an attractive new research and development opportunity to improve drug formulation and administration of existing active pharmaceutical ingredients. Graphical abstract
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