Early experience with targeted therapy and dendritic cell vaccine in metastatic renal cell carcinoma after nephrectomy
PURPOSE: Metastatic renal cell carcinoma (RCC) is one of the most treatment-resistant malignancies and nephrectomy, isolated or combined with systemic chemotherapy typically has limited or no effectiveness. We report our initial results in patients treated with the association of molecular targeted...
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Sociedade Brasileira de Urologia
2011-04-01
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doaj-704a0ae72d0c440c8d83203c6561c8b02020-11-24T22:17:50ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192011-04-0137218018610.1590/S1677-55382011000200004Early experience with targeted therapy and dendritic cell vaccine in metastatic renal cell carcinoma after nephrectomyMarcos F. Dall'OglioJuliana M. Sousa-CanavezFabio Y. TannoBruno C. TiseoAlexandre CrippaSabrina T. dos ReisKatia R. M. LeiteMiguel SrougiPURPOSE: Metastatic renal cell carcinoma (RCC) is one of the most treatment-resistant malignancies and nephrectomy, isolated or combined with systemic chemotherapy typically has limited or no effectiveness. We report our initial results in patients treated with the association of molecular targeted therapy, nephrectomy, and hybrid dendritic-tumor cell (DC) vaccine. MATERIALS AND METHODS: Two male patients diagnosed with metastatic RCC were selected for the study. They were treated with the triple strategy, in which sunitinib (50 mg per day) was given for 4 weeks, followed by radical nephrectomy after two weeks. DC vaccine was initiated immediately after surgery and repeated monthly. Sunitinib was restarted daily after 2 to 3 weeks of surgery with a 7-day interval every 4 weeks. RESULTS: Both patients had complete adherence to the proposed treatment with DC vaccine therapy combined with sunitinib. Follow-up in these patients at 9 and 10 months demonstrated a stable disease in both, as shown by imaging and clinical findings, with no further treatment required. CONCLUSION: The immune response obtained with DC vaccine combined with the antiangiogenic effect of sunitinib and the potential benefits of cytoreductive nephrectomy in advanced disease could represent a new option in the treatment of metastatic RCC. Further prospective trials are needed not only to elucidate the ideal dosing and schedule, but also to better define the proof-of-concept proposed in this report and its role in clinical practice.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382011000200004renal cell carcinomadendritic cellsneoplasm metastasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcos F. Dall'Oglio Juliana M. Sousa-Canavez Fabio Y. Tanno Bruno C. Tiseo Alexandre Crippa Sabrina T. dos Reis Katia R. M. Leite Miguel Srougi |
spellingShingle |
Marcos F. Dall'Oglio Juliana M. Sousa-Canavez Fabio Y. Tanno Bruno C. Tiseo Alexandre Crippa Sabrina T. dos Reis Katia R. M. Leite Miguel Srougi Early experience with targeted therapy and dendritic cell vaccine in metastatic renal cell carcinoma after nephrectomy International Brazilian Journal of Urology renal cell carcinoma dendritic cells neoplasm metastasis |
author_facet |
Marcos F. Dall'Oglio Juliana M. Sousa-Canavez Fabio Y. Tanno Bruno C. Tiseo Alexandre Crippa Sabrina T. dos Reis Katia R. M. Leite Miguel Srougi |
author_sort |
Marcos F. Dall'Oglio |
title |
Early experience with targeted therapy and dendritic cell vaccine in metastatic renal cell carcinoma after nephrectomy |
title_short |
Early experience with targeted therapy and dendritic cell vaccine in metastatic renal cell carcinoma after nephrectomy |
title_full |
Early experience with targeted therapy and dendritic cell vaccine in metastatic renal cell carcinoma after nephrectomy |
title_fullStr |
Early experience with targeted therapy and dendritic cell vaccine in metastatic renal cell carcinoma after nephrectomy |
title_full_unstemmed |
Early experience with targeted therapy and dendritic cell vaccine in metastatic renal cell carcinoma after nephrectomy |
title_sort |
early experience with targeted therapy and dendritic cell vaccine in metastatic renal cell carcinoma after nephrectomy |
publisher |
Sociedade Brasileira de Urologia |
series |
International Brazilian Journal of Urology |
issn |
1677-5538 1677-6119 |
publishDate |
2011-04-01 |
description |
PURPOSE: Metastatic renal cell carcinoma (RCC) is one of the most treatment-resistant malignancies and nephrectomy, isolated or combined with systemic chemotherapy typically has limited or no effectiveness. We report our initial results in patients treated with the association of molecular targeted therapy, nephrectomy, and hybrid dendritic-tumor cell (DC) vaccine. MATERIALS AND METHODS: Two male patients diagnosed with metastatic RCC were selected for the study. They were treated with the triple strategy, in which sunitinib (50 mg per day) was given for 4 weeks, followed by radical nephrectomy after two weeks. DC vaccine was initiated immediately after surgery and repeated monthly. Sunitinib was restarted daily after 2 to 3 weeks of surgery with a 7-day interval every 4 weeks. RESULTS: Both patients had complete adherence to the proposed treatment with DC vaccine therapy combined with sunitinib. Follow-up in these patients at 9 and 10 months demonstrated a stable disease in both, as shown by imaging and clinical findings, with no further treatment required. CONCLUSION: The immune response obtained with DC vaccine combined with the antiangiogenic effect of sunitinib and the potential benefits of cytoreductive nephrectomy in advanced disease could represent a new option in the treatment of metastatic RCC. Further prospective trials are needed not only to elucidate the ideal dosing and schedule, but also to better define the proof-of-concept proposed in this report and its role in clinical practice. |
topic |
renal cell carcinoma dendritic cells neoplasm metastasis |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382011000200004 |
work_keys_str_mv |
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