Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma

Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma

Papillary hidradenoma/ mammary-like gland adenoma (MLGA) is a benign glandular tumor of the vulva. It presents as a mass lesion which often undergoes secondary ulceration and bleeding resembling a malignant tumor. It arises from specialized anogenital glands in the labial folds which resemble mammar...

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Main Authors: Deval Parekh, Sunaina Wadhwa, Asima Mukhopadhyay, Angad Singh
Format: Article
Language:English
Published: Barpeta Obstetrics and Gynaecological Society 2021-07-01
Series:New Indian Journal of OBGYN
Subjects:
mammary like gland adenoma
papillary hidradenoma
vulva
gata-3
Online Access:https://journal.barpetaogs.co.in/pdf/08143.pdf
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spelling doaj-704ba7b6a898482892a0a9968b98a4e72021-07-26T16:23:48ZengBarpeta Obstetrics and Gynaecological SocietyNew Indian Journal of OBGYN2454-23342454-23422021-07-018114314510.21276/obgyn.2021.8.1.28Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinomaDeval Parekh0Sunaina Wadhwa1Asima Mukhopadhyay2Angad Singh3Department of Pathology, Tata Medical Center, Kolkata, IndiaDepartment of Gynaecologic Oncology, Tata Medical Center, Kolkata, IndiaDepartment of Gynaecologic Oncology, Tata Medical Center, Kolkata, IndiaDepartment of Pathology, Tata Medical Center, Kolkata, IndiaPapillary hidradenoma/ mammary-like gland adenoma (MLGA) is a benign glandular tumor of the vulva. It presents as a mass lesion which often undergoes secondary ulceration and bleeding resembling a malignant tumor. It arises from specialized anogenital glands in the labial folds which resemble mammary glands on microscopy. The tumour shows a tubulo-papillary architecture and is composed of bland columnar cells with apical snouting. GATA-3 is a transcription factor and it’s expression is essential for normal mammary gland development. GATA-3 immunohistochemistry (IHC) is positive in luminal cells of breast and its positive in ductal hyperplasia as well as in breast carcinoma. In summary, we describe a case of a benign vulval mammary gland like adenoma with diffuse GATA-3 expression which was originally diagnosed as a malignant low-grade polymorphous adenocarcinoma and discuss its clinical and associated histopathological findings.https://journal.barpetaogs.co.in/pdf/08143.pdfmammary like gland adenomapapillary hidradenomavulvagata-3
collection DOAJ
language English
format Article
sources DOAJ
author Deval Parekh
Sunaina Wadhwa
Asima Mukhopadhyay
Angad Singh
spellingShingle Deval Parekh
Sunaina Wadhwa
Asima Mukhopadhyay
Angad Singh
Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma
New Indian Journal of OBGYN
mammary like gland adenoma
papillary hidradenoma
vulva
gata-3
author_facet Deval Parekh
Sunaina Wadhwa
Asima Mukhopadhyay
Angad Singh
author_sort Deval Parekh
title Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma
title_short Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma
title_full Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma
title_fullStr Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma
title_full_unstemmed Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma
title_sort mammary like gland adenoma with gata-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma
publisher Barpeta Obstetrics and Gynaecological Society
series New Indian Journal of OBGYN
issn 2454-2334
2454-2342
publishDate 2021-07-01
description Papillary hidradenoma/ mammary-like gland adenoma (MLGA) is a benign glandular tumor of the vulva. It presents as a mass lesion which often undergoes secondary ulceration and bleeding resembling a malignant tumor. It arises from specialized anogenital glands in the labial folds which resemble mammary glands on microscopy. The tumour shows a tubulo-papillary architecture and is composed of bland columnar cells with apical snouting. GATA-3 is a transcription factor and it’s expression is essential for normal mammary gland development. GATA-3 immunohistochemistry (IHC) is positive in luminal cells of breast and its positive in ductal hyperplasia as well as in breast carcinoma. In summary, we describe a case of a benign vulval mammary gland like adenoma with diffuse GATA-3 expression which was originally diagnosed as a malignant low-grade polymorphous adenocarcinoma and discuss its clinical and associated histopathological findings.
topic mammary like gland adenoma
papillary hidradenoma
vulva
gata-3
url https://journal.barpetaogs.co.in/pdf/08143.pdf
work_keys_str_mv AT devalparekh mammarylikeglandadenomawithgata3expressionabenignvulvaltumorwithmammarydifferentiationoftenmisdiagnosedasadenocarcinoma
AT sunainawadhwa mammarylikeglandadenomawithgata3expressionabenignvulvaltumorwithmammarydifferentiationoftenmisdiagnosedasadenocarcinoma
AT asimamukhopadhyay mammarylikeglandadenomawithgata3expressionabenignvulvaltumorwithmammarydifferentiationoftenmisdiagnosedasadenocarcinoma
AT angadsingh mammarylikeglandadenomawithgata3expressionabenignvulvaltumorwithmammarydifferentiationoftenmisdiagnosedasadenocarcinoma
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