Thiol-based H2O2 signalling in microbial systems
Cysteine residues, and in particular their thiolate groups, react not only with reactive oxygen species but also with electrophiles and with reactive nitrogen species. Thus, cysteine oxidation has often been linked to the toxic effects of some of these reactive molecules. However, thiol-based switc...
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231714000305 |
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doaj-705108d7f2a04e168fb259dcee159e252020-11-25T02:40:22ZengElsevierRedox Biology2213-23172014-01-012C39539910.1016/j.redox.2014.01.015Thiol-based H2O2 signalling in microbial systemsSusanna BoronatAlba DomènechEsther PauloIsabel A. CalvoSarela García-SantamarinaPatricia GarcíaJavier Encinar del DedoAnna BarconsErica SerranoMercè CarmonaElena Hidalgo Cysteine residues, and in particular their thiolate groups, react not only with reactive oxygen species but also with electrophiles and with reactive nitrogen species. Thus, cysteine oxidation has often been linked to the toxic effects of some of these reactive molecules. However, thiol-based switches are common in protein sensors of antioxidant cascades, in both prokaryotic and eukaryotic organisms. We will describe here three redox sensors, the transcription factors OxyR, Yap1 and Pap1, which respond by disulfide bond formation to hydrogen peroxide stress, focusing specially on the differences among the three peroxide-sensing mechanisms. http://www.sciencedirect.com/science/article/pii/S2213231714000305H2O2 sensorCys oxidationOxyRPap1Yap1S. pombe |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Susanna Boronat Alba Domènech Esther Paulo Isabel A. Calvo Sarela García-Santamarina Patricia García Javier Encinar del Dedo Anna Barcons Erica Serrano Mercè Carmona Elena Hidalgo |
spellingShingle |
Susanna Boronat Alba Domènech Esther Paulo Isabel A. Calvo Sarela García-Santamarina Patricia García Javier Encinar del Dedo Anna Barcons Erica Serrano Mercè Carmona Elena Hidalgo Thiol-based H2O2 signalling in microbial systems Redox Biology H2O2 sensor Cys oxidation OxyR Pap1 Yap1 S. pombe |
author_facet |
Susanna Boronat Alba Domènech Esther Paulo Isabel A. Calvo Sarela García-Santamarina Patricia García Javier Encinar del Dedo Anna Barcons Erica Serrano Mercè Carmona Elena Hidalgo |
author_sort |
Susanna Boronat |
title |
Thiol-based H2O2 signalling in microbial systems |
title_short |
Thiol-based H2O2 signalling in microbial systems |
title_full |
Thiol-based H2O2 signalling in microbial systems |
title_fullStr |
Thiol-based H2O2 signalling in microbial systems |
title_full_unstemmed |
Thiol-based H2O2 signalling in microbial systems |
title_sort |
thiol-based h2o2 signalling in microbial systems |
publisher |
Elsevier |
series |
Redox Biology |
issn |
2213-2317 |
publishDate |
2014-01-01 |
description |
Cysteine residues, and in particular their thiolate groups, react not only with reactive oxygen species but also with electrophiles and with reactive nitrogen species. Thus, cysteine oxidation has often been linked to the toxic effects of some of these reactive molecules. However, thiol-based switches are common in protein sensors of antioxidant cascades, in both prokaryotic and eukaryotic organisms. We will describe here three redox sensors, the transcription factors OxyR, Yap1 and Pap1, which respond by disulfide bond formation to hydrogen peroxide stress, focusing specially on the differences among the three peroxide-sensing mechanisms.
|
topic |
H2O2 sensor Cys oxidation OxyR Pap1 Yap1 S. pombe |
url |
http://www.sciencedirect.com/science/article/pii/S2213231714000305 |
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1724782153240150016 |