Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction

Purpose: To report a case of a successful Descemet's membrane endothelial keratoplasty (DMEK) facilitated by the use of intracameral tissue plasminogen activator (tPA) in a 4-year old with posterior polymorphous corneal dystrophy (PPCD). Observations: A 4-year old male was referred for bilatera...

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Main Authors: Tanner J. Ferguson, Elias I. Traboulsi, Jeffrey M. Goshe
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:American Journal of Ophthalmology Case Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2451993620301456
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spelling doaj-70540309971b41559340930f98294bb52020-11-25T03:49:36ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362020-09-0119100812Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reactionTanner J. Ferguson0Elias I. Traboulsi1Jeffrey M. Goshe2Corresponding author.; Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USACole Eye Institute, Cleveland Clinic, Cleveland, OH, USACole Eye Institute, Cleveland Clinic, Cleveland, OH, USAPurpose: To report a case of a successful Descemet's membrane endothelial keratoplasty (DMEK) facilitated by the use of intracameral tissue plasminogen activator (tPA) in a 4-year old with posterior polymorphous corneal dystrophy (PPCD). Observations: A 4-year old male was referred for bilateral corneal haze and blurry vision. Patient's exam and genetic testing were consistent with a diagnosis of PPCD. Patient was successfully treated with DMEK augmented by the use of intracameral tPA intraoperatively to combat the anterior chamber fibrin formation that can occur in DMEK. Conclusions: To our knowledge, this case represents the youngest reported successful DMEK procedure and the first case describing the use of intracameral tPA intraoperatively to attenuate the anterior chamber fibrin formation that can occur in DMEK.http://www.sciencedirect.com/science/article/pii/S2451993620301456DMEKEndothelial keratoplastyFibrinSurgical complications
collection DOAJ
language English
format Article
sources DOAJ
author Tanner J. Ferguson
Elias I. Traboulsi
Jeffrey M. Goshe
spellingShingle Tanner J. Ferguson
Elias I. Traboulsi
Jeffrey M. Goshe
Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction
American Journal of Ophthalmology Case Reports
DMEK
Endothelial keratoplasty
Fibrin
Surgical complications
author_facet Tanner J. Ferguson
Elias I. Traboulsi
Jeffrey M. Goshe
author_sort Tanner J. Ferguson
title Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction
title_short Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction
title_full Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction
title_fullStr Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction
title_full_unstemmed Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction
title_sort successful pediatric dmek facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction
publisher Elsevier
series American Journal of Ophthalmology Case Reports
issn 2451-9936
publishDate 2020-09-01
description Purpose: To report a case of a successful Descemet's membrane endothelial keratoplasty (DMEK) facilitated by the use of intracameral tissue plasminogen activator (tPA) in a 4-year old with posterior polymorphous corneal dystrophy (PPCD). Observations: A 4-year old male was referred for bilateral corneal haze and blurry vision. Patient's exam and genetic testing were consistent with a diagnosis of PPCD. Patient was successfully treated with DMEK augmented by the use of intracameral tPA intraoperatively to combat the anterior chamber fibrin formation that can occur in DMEK. Conclusions: To our knowledge, this case represents the youngest reported successful DMEK procedure and the first case describing the use of intracameral tPA intraoperatively to attenuate the anterior chamber fibrin formation that can occur in DMEK.
topic DMEK
Endothelial keratoplasty
Fibrin
Surgical complications
url http://www.sciencedirect.com/science/article/pii/S2451993620301456
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