Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction
Purpose: To report a case of a successful Descemet's membrane endothelial keratoplasty (DMEK) facilitated by the use of intracameral tissue plasminogen activator (tPA) in a 4-year old with posterior polymorphous corneal dystrophy (PPCD). Observations: A 4-year old male was referred for bilatera...
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doaj-70540309971b41559340930f98294bb52020-11-25T03:49:36ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362020-09-0119100812Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reactionTanner J. Ferguson0Elias I. Traboulsi1Jeffrey M. Goshe2Corresponding author.; Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USACole Eye Institute, Cleveland Clinic, Cleveland, OH, USACole Eye Institute, Cleveland Clinic, Cleveland, OH, USAPurpose: To report a case of a successful Descemet's membrane endothelial keratoplasty (DMEK) facilitated by the use of intracameral tissue plasminogen activator (tPA) in a 4-year old with posterior polymorphous corneal dystrophy (PPCD). Observations: A 4-year old male was referred for bilateral corneal haze and blurry vision. Patient's exam and genetic testing were consistent with a diagnosis of PPCD. Patient was successfully treated with DMEK augmented by the use of intracameral tPA intraoperatively to combat the anterior chamber fibrin formation that can occur in DMEK. Conclusions: To our knowledge, this case represents the youngest reported successful DMEK procedure and the first case describing the use of intracameral tPA intraoperatively to attenuate the anterior chamber fibrin formation that can occur in DMEK.http://www.sciencedirect.com/science/article/pii/S2451993620301456DMEKEndothelial keratoplastyFibrinSurgical complications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tanner J. Ferguson Elias I. Traboulsi Jeffrey M. Goshe |
spellingShingle |
Tanner J. Ferguson Elias I. Traboulsi Jeffrey M. Goshe Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction American Journal of Ophthalmology Case Reports DMEK Endothelial keratoplasty Fibrin Surgical complications |
author_facet |
Tanner J. Ferguson Elias I. Traboulsi Jeffrey M. Goshe |
author_sort |
Tanner J. Ferguson |
title |
Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction |
title_short |
Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction |
title_full |
Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction |
title_fullStr |
Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction |
title_full_unstemmed |
Successful pediatric DMEK facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction |
title_sort |
successful pediatric dmek facilitated by intracameral tissue plasminogen activator to mitigate anterior chamber fibrin reaction |
publisher |
Elsevier |
series |
American Journal of Ophthalmology Case Reports |
issn |
2451-9936 |
publishDate |
2020-09-01 |
description |
Purpose: To report a case of a successful Descemet's membrane endothelial keratoplasty (DMEK) facilitated by the use of intracameral tissue plasminogen activator (tPA) in a 4-year old with posterior polymorphous corneal dystrophy (PPCD). Observations: A 4-year old male was referred for bilateral corneal haze and blurry vision. Patient's exam and genetic testing were consistent with a diagnosis of PPCD. Patient was successfully treated with DMEK augmented by the use of intracameral tPA intraoperatively to combat the anterior chamber fibrin formation that can occur in DMEK. Conclusions: To our knowledge, this case represents the youngest reported successful DMEK procedure and the first case describing the use of intracameral tPA intraoperatively to attenuate the anterior chamber fibrin formation that can occur in DMEK. |
topic |
DMEK Endothelial keratoplasty Fibrin Surgical complications |
url |
http://www.sciencedirect.com/science/article/pii/S2451993620301456 |
work_keys_str_mv |
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