A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma

A three-dimensional organoid model recapitulates tumorigenic aspects and drug responses of advanced human retinoblastoma

Abstract Persistent or recurrent retinoblastoma (RB) is associated with the presence of vitreous or/and subretinal seeds in advanced RB and represents a major cause of therapeutic failure. This necessitates the development of novel therapies and thus requires a model of advanced RB for testing candi...

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Bibliographic Details
Main Authors: Duangporn Saengwimol, Duangnate Rojanaporn, Vijender Chaitankar, Pamorn Chittavanich, Rangsima Aroonroch, Tatpong Boontawon, Weerin Thammachote, Natini Jinawath, Suradej Hongeng, Rossukon Kaewkhaw
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Organoid Models
Retinal Tumors
Subretinal Seeds
Combined Drug Regimens
Topotecan
Online Access:https://doi.org/10.1038/s41598-018-34037-y

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