Time-Staged Gamma Knife Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations: A Preliminary Report.
We retrospectively analyzed our experience with time-staged gamma knife stereotactic radiosurgery (GKS) in treating large arteriovenous malformation(AVM)s;≥ 10 cm3).Forty-five patients who underwent time-staged GKS (2-stage, n = 37;3-stage,n = 8) between March 1998 and December 2011 were included. T...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5091869?pdf=render |
id |
doaj-7061d3dec412418da2f5064faf2eeddf |
---|---|
record_format |
Article |
spelling |
doaj-7061d3dec412418da2f5064faf2eeddf2020-11-25T01:45:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016578310.1371/journal.pone.0165783Time-Staged Gamma Knife Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations: A Preliminary Report.Hye Ran ParkJae Meen LeeJin Wook KimJung-Ho HanHyun-Tai ChungMoon Hee HanDong Gyu KimSun Ha PaekWe retrospectively analyzed our experience with time-staged gamma knife stereotactic radiosurgery (GKS) in treating large arteriovenous malformation(AVM)s;≥ 10 cm3).Forty-five patients who underwent time-staged GKS (2-stage, n = 37;3-stage,n = 8) between March 1998 and December 2011 were included. The mean volume treated was 20.42±6.29 cm3 (range, 10.20-38.50 cm3). Obliteration rates of AVMs and the associated complications after GKS were evaluated.Mean AVM volume (and median marginal dose) at each GKS session in the 37 patients who underwent 2-stage GKS was 19.67±6.08 cm3 (13 Gy) at session 1 and 6.97±6.92 cm3 (17 Gy) at session 2. The median interval period was 39 months. After follow-up period of 37 months, the complete obliteration rate was 64.9%. The mean AVM volume (and median marginal dose) at each GKS session in the 8 patients who underwent 3-stage GKS was 23.90±6.50 cm3 (12.25 Gy), 19.43±7.46 cm3 (13.5 Gy), 7.48±6.86 cm3 (15.5 Gy) at session 1, 2, and 3, respectively. The median interval duration between each GKS session was 37.5 and 38 months, respectively. After a median follow-up period of 47.5 months, 5 patients (62.5%) achieved complete obliteration. Postradiosurgical hemorrhage developed in 5 patients (11.1%) including one case of major bleeding and 4 cases of minor bleeding. No patient suffered from clinically symptomatic radiation necrosis following radiation.Time-staged GKS could be an effective and safe treatment option in the management of large AVMs.http://europepmc.org/articles/PMC5091869?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hye Ran Park Jae Meen Lee Jin Wook Kim Jung-Ho Han Hyun-Tai Chung Moon Hee Han Dong Gyu Kim Sun Ha Paek |
spellingShingle |
Hye Ran Park Jae Meen Lee Jin Wook Kim Jung-Ho Han Hyun-Tai Chung Moon Hee Han Dong Gyu Kim Sun Ha Paek Time-Staged Gamma Knife Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations: A Preliminary Report. PLoS ONE |
author_facet |
Hye Ran Park Jae Meen Lee Jin Wook Kim Jung-Ho Han Hyun-Tai Chung Moon Hee Han Dong Gyu Kim Sun Ha Paek |
author_sort |
Hye Ran Park |
title |
Time-Staged Gamma Knife Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations: A Preliminary Report. |
title_short |
Time-Staged Gamma Knife Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations: A Preliminary Report. |
title_full |
Time-Staged Gamma Knife Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations: A Preliminary Report. |
title_fullStr |
Time-Staged Gamma Knife Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations: A Preliminary Report. |
title_full_unstemmed |
Time-Staged Gamma Knife Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations: A Preliminary Report. |
title_sort |
time-staged gamma knife stereotactic radiosurgery for large cerebral arteriovenous malformations: a preliminary report. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
We retrospectively analyzed our experience with time-staged gamma knife stereotactic radiosurgery (GKS) in treating large arteriovenous malformation(AVM)s;≥ 10 cm3).Forty-five patients who underwent time-staged GKS (2-stage, n = 37;3-stage,n = 8) between March 1998 and December 2011 were included. The mean volume treated was 20.42±6.29 cm3 (range, 10.20-38.50 cm3). Obliteration rates of AVMs and the associated complications after GKS were evaluated.Mean AVM volume (and median marginal dose) at each GKS session in the 37 patients who underwent 2-stage GKS was 19.67±6.08 cm3 (13 Gy) at session 1 and 6.97±6.92 cm3 (17 Gy) at session 2. The median interval period was 39 months. After follow-up period of 37 months, the complete obliteration rate was 64.9%. The mean AVM volume (and median marginal dose) at each GKS session in the 8 patients who underwent 3-stage GKS was 23.90±6.50 cm3 (12.25 Gy), 19.43±7.46 cm3 (13.5 Gy), 7.48±6.86 cm3 (15.5 Gy) at session 1, 2, and 3, respectively. The median interval duration between each GKS session was 37.5 and 38 months, respectively. After a median follow-up period of 47.5 months, 5 patients (62.5%) achieved complete obliteration. Postradiosurgical hemorrhage developed in 5 patients (11.1%) including one case of major bleeding and 4 cases of minor bleeding. No patient suffered from clinically symptomatic radiation necrosis following radiation.Time-staged GKS could be an effective and safe treatment option in the management of large AVMs. |
url |
http://europepmc.org/articles/PMC5091869?pdf=render |
work_keys_str_mv |
AT hyeranpark timestagedgammaknifestereotacticradiosurgeryforlargecerebralarteriovenousmalformationsapreliminaryreport AT jaemeenlee timestagedgammaknifestereotacticradiosurgeryforlargecerebralarteriovenousmalformationsapreliminaryreport AT jinwookkim timestagedgammaknifestereotacticradiosurgeryforlargecerebralarteriovenousmalformationsapreliminaryreport AT junghohan timestagedgammaknifestereotacticradiosurgeryforlargecerebralarteriovenousmalformationsapreliminaryreport AT hyuntaichung timestagedgammaknifestereotacticradiosurgeryforlargecerebralarteriovenousmalformationsapreliminaryreport AT moonheehan timestagedgammaknifestereotacticradiosurgeryforlargecerebralarteriovenousmalformationsapreliminaryreport AT donggyukim timestagedgammaknifestereotacticradiosurgeryforlargecerebralarteriovenousmalformationsapreliminaryreport AT sunhapaek timestagedgammaknifestereotacticradiosurgeryforlargecerebralarteriovenousmalformationsapreliminaryreport |
_version_ |
1725024840979578880 |