Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model
The purpose of this study was to determine the concentration polarization of high-density lipoprotein (HDL) at the surface of the carotid artery under conditions of steady flow and to establish its relationship with shear stress using an in vitro vascular simulation model of carotid bifurcation. She...
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doaj-706558ef51ff48888e66aaba7cc246a52020-11-24T20:48:18ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512009-01-01200910.1155/2009/695838695838Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro ModelWei Meng0Fengxu Yu1Huaiqing Chen2Jianmin Zhang3Eryong Zhang4Ke Dian5Yingkang Shi6Department of Thoracic and Cardiovascular Surgery, West China Medical Center, Sichuan University, Chengdu 610041, ChinaDepartment of Thoracic and Cardiovascular Surgery, West China Medical Center, Sichuan University, Chengdu 610041, ChinaWest China Medical Center, Institute of Biomedical Engineering, Sichuan University, Chengdu 610041, ChinaState Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610065, ChinaDepartment of Thoracic and Cardiovascular Surgery, West China Medical Center, Sichuan University, Chengdu 610041, ChinaDepartment of Thoracic and Cardiovascular Surgery, West China Medical Center, Sichuan University, Chengdu 610041, ChinaDepartment of Thoracic and Cardiovascular Surgery, West China Medical Center, Sichuan University, Chengdu 610041, ChinaThe purpose of this study was to determine the concentration polarization of high-density lipoprotein (HDL) at the surface of the carotid artery under conditions of steady flow and to establish its relationship with shear stress using an in vitro vascular simulation model of carotid bifurcation. Shear stress, HDL concentration at the surface, and the ratio of HDL concentration at the surface to concentration in bulk flow were measured at different locations within the model under high-speed (1.451 m/s) and low-speed (0.559 m/s) flow. HDL showed concentration polarization at the surface of the carotid artery model, particularly in the internal carotid artery sinus. With decreasing flow velocity, the shear stress at the surface also decreased, and HDL concentration polarization increased. The concentration polarization of HDL was negatively and strongly correlated with shear stress at both low- (r=−0.872, P<.001) and high-speed flow (r=−0.592, P=.0018).http://dx.doi.org/10.1155/2009/695838 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Meng Fengxu Yu Huaiqing Chen Jianmin Zhang Eryong Zhang Ke Dian Yingkang Shi |
spellingShingle |
Wei Meng Fengxu Yu Huaiqing Chen Jianmin Zhang Eryong Zhang Ke Dian Yingkang Shi Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model Journal of Biomedicine and Biotechnology |
author_facet |
Wei Meng Fengxu Yu Huaiqing Chen Jianmin Zhang Eryong Zhang Ke Dian Yingkang Shi |
author_sort |
Wei Meng |
title |
Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model |
title_short |
Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model |
title_full |
Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model |
title_fullStr |
Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model |
title_full_unstemmed |
Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model |
title_sort |
concentration polarization of high-density lipoprotein and its relation with shear stress in an in vitro model |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2009-01-01 |
description |
The purpose of this study was to determine the concentration polarization of high-density lipoprotein (HDL) at the surface of the carotid artery under conditions of steady flow and to establish its relationship with shear stress using an in vitro vascular simulation model of carotid bifurcation. Shear stress, HDL concentration at the surface, and the ratio of HDL concentration at the surface to concentration in bulk flow were measured at different locations within the model under high-speed (1.451 m/s) and low-speed (0.559 m/s) flow. HDL showed concentration polarization at the surface of the carotid artery model, particularly in the internal carotid artery sinus. With decreasing flow velocity, the shear stress at the surface also decreased, and HDL concentration polarization increased. The concentration polarization of HDL was negatively and strongly correlated with shear stress at both low- (r=−0.872, P<.001) and high-speed flow (r=−0.592, P=.0018). |
url |
http://dx.doi.org/10.1155/2009/695838 |
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