Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-...

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Bibliographic Details
Main Authors: Søren Wedel Svenningsen, Rikki Franklin Frederiksen, Claire Counil, Mario Ficker, Jørgen J. Leisner, Jørn Bolstad Christensen
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
antimicrobial compounds
dendrimers
ciprofloxacin
Online Access:https://www.mdpi.com/1420-3049/25/6/1389
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spelling doaj-706d3e6863db4fabbd464075775fa7722020-11-25T03:10:06ZengMDPI AGMolecules1420-30492020-03-01256138910.3390/molecules25061389molecules25061389Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer ConjugateSøren Wedel Svenningsen0Rikki Franklin Frederiksen1Claire Counil2Mario Ficker3Jørgen J. Leisner4Jørn Bolstad Christensen5Department of Chemistry, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, DenmarkDepartment of Veterinary and Animal Sciences, Food Safety and Zoonoses, University of Copenhagen, Grønnegårdsvej 15, DK-1870 Frederiksberg C, DenmarkDepartment of Chemistry, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, DenmarkDepartment of Chemistry, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, DenmarkDepartment of Veterinary and Animal Sciences, Food Safety and Zoonoses, University of Copenhagen, Grønnegårdsvej 15, DK-1870 Frederiksberg C, DenmarkDepartment of Chemistry, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, DenmarkInfections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.https://www.mdpi.com/1420-3049/25/6/1389antimicrobial compoundsdendrimersciprofloxacin
collection DOAJ
language English
format Article
sources DOAJ
author Søren Wedel Svenningsen
Rikki Franklin Frederiksen
Claire Counil
Mario Ficker
Jørgen J. Leisner
Jørn Bolstad Christensen
spellingShingle Søren Wedel Svenningsen
Rikki Franklin Frederiksen
Claire Counil
Mario Ficker
Jørgen J. Leisner
Jørn Bolstad Christensen
Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
Molecules
antimicrobial compounds
dendrimers
ciprofloxacin
author_facet Søren Wedel Svenningsen
Rikki Franklin Frederiksen
Claire Counil
Mario Ficker
Jørgen J. Leisner
Jørn Bolstad Christensen
author_sort Søren Wedel Svenningsen
title Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title_short Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title_full Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title_fullStr Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title_full_unstemmed Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
title_sort synthesis and antimicrobial properties of a ciprofloxacin and pamam-dendrimer conjugate
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2020-03-01
description Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.
topic antimicrobial compounds
dendrimers
ciprofloxacin
url https://www.mdpi.com/1420-3049/25/6/1389
work_keys_str_mv AT sørenwedelsvenningsen synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
AT rikkifranklinfrederiksen synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
AT clairecounil synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
AT marioficker synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
AT jørgenjleisner synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
AT jørnbolstadchristensen synthesisandantimicrobialpropertiesofaciprofloxacinandpamamdendrimerconjugate
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