EPIDEMIOLOGY AND PATHOPHYSIOLOGICAL MECHANISMS INVOLVED IN ALTERATION OF GLOMERULAR FUNCTION IN DIABETIC PATIENTS
Chronic kidney disease of diabetic cause is a highly prevalent complication in diabetes mellitus patients. Complex phenotypes of the disease start to be recognized, such as albuminuria (micro- or macroalbuminuria) and non-albuminuric phenotype reduced glomerular filtration rate <60 mL/min/1.73m2....
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doaj-70702e2c1e0743349d122773aa82606a2021-04-02T18:46:55ZengBalkan Medical UnionArchives of the Balkan Medical Union1584-92442558-815X2021-03-0156194100https://doi.org/10.31688/ABMU.2021.56.1.12EPIDEMIOLOGY AND PATHOPHYSIOLOGICAL MECHANISMS INVOLVED IN ALTERATION OF GLOMERULAR FUNCTION IN DIABETIC PATIENTSMarcel STOITA0Areha Abid1Cosmin VESA2Raluca A. CORB ARON3Timea C. GHITEA4Gabriela ANGELESCU5Amorin POPA6Faculty of Medicine and Pharmacy, University of Oradea, Oradea, RomaniaFaculty of Agricultural and Food Sciences, University of Debrecen, Debrecen, HungaryFaculty of Medicine and Pharmacy, University of Oradea, Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, Oradea, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania“Carol Davila” University of Medicine and Pharmacy, Internal Medicine Clinic, Clinical Emergency Hospital of Ilfov County, Bucharest, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, Oradea, RomaniaChronic kidney disease of diabetic cause is a highly prevalent complication in diabetes mellitus patients. Complex phenotypes of the disease start to be recognized, such as albuminuria (micro- or macroalbuminuria) and non-albuminuric phenotype reduced glomerular filtration rate <60 mL/min/1.73m2. Numerous pathogenic pathways contribute to the development of this disorder, as follows: the alterations of glucose metabolism with excess degradation of glucose on alternative pathways, hemodynamic changes, glomerulosclerosis, inflammation. As this review demonstrates once more, all these pathophysiological modifications can be linked to hyperglycaemia. Both glomerular and tubular interstitial lesions occur and contribute to disease progression. Adequate glycaemic control and an early diagnosis of diabetes mellitus are key measures in preventing this complication.https://umbalk.org/epidemiology-and-pathophysiological-mechanisms-involved-in-alteration-of-glomerular-function-in-diabetic-patients/epidemiologydiabeteschronic kidney diseaseglomerular functioninsulin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcel STOITA Areha Abid Cosmin VESA Raluca A. CORB ARON Timea C. GHITEA Gabriela ANGELESCU Amorin POPA |
spellingShingle |
Marcel STOITA Areha Abid Cosmin VESA Raluca A. CORB ARON Timea C. GHITEA Gabriela ANGELESCU Amorin POPA EPIDEMIOLOGY AND PATHOPHYSIOLOGICAL MECHANISMS INVOLVED IN ALTERATION OF GLOMERULAR FUNCTION IN DIABETIC PATIENTS Archives of the Balkan Medical Union epidemiology diabetes chronic kidney disease glomerular function insulin |
author_facet |
Marcel STOITA Areha Abid Cosmin VESA Raluca A. CORB ARON Timea C. GHITEA Gabriela ANGELESCU Amorin POPA |
author_sort |
Marcel STOITA |
title |
EPIDEMIOLOGY AND PATHOPHYSIOLOGICAL MECHANISMS INVOLVED IN ALTERATION OF GLOMERULAR FUNCTION IN DIABETIC PATIENTS |
title_short |
EPIDEMIOLOGY AND PATHOPHYSIOLOGICAL MECHANISMS INVOLVED IN ALTERATION OF GLOMERULAR FUNCTION IN DIABETIC PATIENTS |
title_full |
EPIDEMIOLOGY AND PATHOPHYSIOLOGICAL MECHANISMS INVOLVED IN ALTERATION OF GLOMERULAR FUNCTION IN DIABETIC PATIENTS |
title_fullStr |
EPIDEMIOLOGY AND PATHOPHYSIOLOGICAL MECHANISMS INVOLVED IN ALTERATION OF GLOMERULAR FUNCTION IN DIABETIC PATIENTS |
title_full_unstemmed |
EPIDEMIOLOGY AND PATHOPHYSIOLOGICAL MECHANISMS INVOLVED IN ALTERATION OF GLOMERULAR FUNCTION IN DIABETIC PATIENTS |
title_sort |
epidemiology and pathophysiological mechanisms involved in alteration of glomerular function in diabetic patients |
publisher |
Balkan Medical Union |
series |
Archives of the Balkan Medical Union |
issn |
1584-9244 2558-815X |
publishDate |
2021-03-01 |
description |
Chronic kidney disease of diabetic cause is a highly prevalent complication in diabetes mellitus patients. Complex phenotypes of the disease start to be recognized, such as albuminuria (micro- or macroalbuminuria) and non-albuminuric phenotype reduced glomerular filtration rate <60 mL/min/1.73m2. Numerous pathogenic pathways contribute to the development of this disorder, as follows: the alterations of glucose metabolism with excess degradation of glucose on alternative pathways, hemodynamic changes, glomerulosclerosis, inflammation. As this review demonstrates once more, all these pathophysiological modifications can be linked to hyperglycaemia. Both glomerular and tubular interstitial lesions occur and contribute to disease progression. Adequate glycaemic control and an early diagnosis of diabetes mellitus are key measures in preventing this complication. |
topic |
epidemiology diabetes chronic kidney disease glomerular function insulin |
url |
https://umbalk.org/epidemiology-and-pathophysiological-mechanisms-involved-in-alteration-of-glomerular-function-in-diabetic-patients/ |
work_keys_str_mv |
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1721550925087113216 |