Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw
Yuanli Chen, Chunlin Zong, Yuxuan Guo, Lei Tian Department of Cranio-facial Trauma and Orthognathic Surgery Laboratory of Military Stomatology, School of Stomatology, The Fourth Military Medical University, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China...
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Dove Medical Press
2015-10-01
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Series: | Therapeutics and Clinical Risk Management |
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doaj-70752e86503742fe98ee0a63ad2f22302020-11-24T22:35:13ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2015-10-012015default1581158524133Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jawChen YZong CGuo YTian LYuanli Chen, Chunlin Zong, Yuxuan Guo, Lei Tian Department of Cranio-facial Trauma and Orthognathic Surgery Laboratory of Military Stomatology, School of Stomatology, The Fourth Military Medical University, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China Abstract: Hydrogen, a therapeutic medical gas, can exert antioxidant activity via selectively reducing cytotoxic reactive oxygen species such as hydroxyl radicals. Hydrogen-rich saline is an alternative form of molecular hydrogen that has been widely used in many studies, including metabolic syndrome, cerebral, hepatic, myocardial ischemia/reperfusion, and liver injuries with obstructive jaundice, with beneficial results. Osteoradionecrosis of the jaw is a serious complication following radiotherapy for head and neck cancers. It has long been known that most radiation-induced symptoms are caused by free radicals generated by radiolysis of H2O, and the hydroxyl radical is the most reactive of these. Reducing the hydroxyl radical can distinctly improve the protection of cells from radiation damage. We hypothesized that hydrogen-rich saline might be an effective and specific method of managing and preventing osteoradionecrosis of the jaw. Keywords: osteoradionecrosis, hydrogen, reactive oxygen specieshttps://www.dovepress.com/hydrogen-rich-saline-may-be-an-effective-and-specific-novel-treatment--peer-reviewed-article-TCRM |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chen Y Zong C Guo Y Tian L |
spellingShingle |
Chen Y Zong C Guo Y Tian L Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw Therapeutics and Clinical Risk Management |
author_facet |
Chen Y Zong C Guo Y Tian L |
author_sort |
Chen Y |
title |
Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw |
title_short |
Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw |
title_full |
Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw |
title_fullStr |
Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw |
title_full_unstemmed |
Hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw |
title_sort |
hydrogen-rich saline may be an effective and specific novel treatment for osteoradionecrosis of the jaw |
publisher |
Dove Medical Press |
series |
Therapeutics and Clinical Risk Management |
issn |
1178-203X |
publishDate |
2015-10-01 |
description |
Yuanli Chen, Chunlin Zong, Yuxuan Guo, Lei Tian Department of Cranio-facial Trauma and Orthognathic Surgery Laboratory of Military Stomatology, School of Stomatology, The Fourth Military Medical University, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China Abstract: Hydrogen, a therapeutic medical gas, can exert antioxidant activity via selectively reducing cytotoxic reactive oxygen species such as hydroxyl radicals. Hydrogen-rich saline is an alternative form of molecular hydrogen that has been widely used in many studies, including metabolic syndrome, cerebral, hepatic, myocardial ischemia/reperfusion, and liver injuries with obstructive jaundice, with beneficial results. Osteoradionecrosis of the jaw is a serious complication following radiotherapy for head and neck cancers. It has long been known that most radiation-induced symptoms are caused by free radicals generated by radiolysis of H2O, and the hydroxyl radical is the most reactive of these. Reducing the hydroxyl radical can distinctly improve the protection of cells from radiation damage. We hypothesized that hydrogen-rich saline might be an effective and specific method of managing and preventing osteoradionecrosis of the jaw. Keywords: osteoradionecrosis, hydrogen, reactive oxygen species |
url |
https://www.dovepress.com/hydrogen-rich-saline-may-be-an-effective-and-specific-novel-treatment--peer-reviewed-article-TCRM |
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