Parkin Co-regulated Gene (PACRG) is regulated by the ubiquitin–proteasomal system and is present in the pathological features of parkinsonian diseases
Mutations in parkin are a common cause of early-onset autosomal recessive Parkinson's disease. Parkin Co-Regulated Gene (PACRG) is a novel gene that was discovered because of its close genetic proximity to parkin and the two genes were subsequently demonstrated to be regulated by a bi-direction...
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doaj-707c0eb6a0ec4f50a0bd8488034795e62021-03-20T04:54:38ZengElsevierNeurobiology of Disease1095-953X2007-08-01272238247Parkin Co-regulated Gene (PACRG) is regulated by the ubiquitin–proteasomal system and is present in the pathological features of parkinsonian diseasesJuliet M. Taylor0Yun Ju C. Song1Yue Huang2Matthew J. Farrer3Martin B. Delatycki4Glenda M. Halliday5Paul J. Lockhart6Bruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Melbourne, Victoria 3052, AustraliaPrince of Wales Medical Research Institute, Randwick, Sydney, AustraliaPrince of Wales Medical Research Institute, Randwick, Sydney, AustraliaDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USABruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Melbourne, Victoria 3052, Australia; Department of Paediatrics, University of Melbourne, Victoria, AustraliaPrince of Wales Medical Research Institute, Randwick, Sydney, AustraliaBruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Melbourne, Victoria 3052, Australia; Department of Paediatrics, University of Melbourne, Victoria, Australia; Corresponding author. Bruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Melbourne, Victoria 3052, Australia. Fax: +61 3 8341 6390.Mutations in parkin are a common cause of early-onset autosomal recessive Parkinson's disease. Parkin Co-Regulated Gene (PACRG) is a novel gene that was discovered because of its close genetic proximity to parkin and the two genes were subsequently demonstrated to be regulated by a bi-directional promoter. However the role of PACRG has not been well characterized and the distribution of the protein in both normal and diseased brain is not known. Here, we report that like parkin, PACRG is regulated by the ubiquitin–proteasomal system. Immunohistochemistry identified PACRG in astrocytes throughout the brain and in pigmented noradrenergic neurons of the locus coeruleus. PACRG was also detected in Lewy bodies and glial cytoplasmic inclusions in patients with Parkinson's disease and Multiple System Atrophy, respectively. Together, these results demonstrate that PACRG is regulated by the ubiquitin–proteasomal system and may play a role in the pathogenesis of Parkinson's disease.http://www.sciencedirect.com/science/article/pii/S0969996107001040PACRGParkinUbiquitin–proteasomal systemLewy bodies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juliet M. Taylor Yun Ju C. Song Yue Huang Matthew J. Farrer Martin B. Delatycki Glenda M. Halliday Paul J. Lockhart |
spellingShingle |
Juliet M. Taylor Yun Ju C. Song Yue Huang Matthew J. Farrer Martin B. Delatycki Glenda M. Halliday Paul J. Lockhart Parkin Co-regulated Gene (PACRG) is regulated by the ubiquitin–proteasomal system and is present in the pathological features of parkinsonian diseases Neurobiology of Disease PACRG Parkin Ubiquitin–proteasomal system Lewy bodies |
author_facet |
Juliet M. Taylor Yun Ju C. Song Yue Huang Matthew J. Farrer Martin B. Delatycki Glenda M. Halliday Paul J. Lockhart |
author_sort |
Juliet M. Taylor |
title |
Parkin Co-regulated Gene (PACRG) is regulated by the ubiquitin–proteasomal system and is present in the pathological features of parkinsonian diseases |
title_short |
Parkin Co-regulated Gene (PACRG) is regulated by the ubiquitin–proteasomal system and is present in the pathological features of parkinsonian diseases |
title_full |
Parkin Co-regulated Gene (PACRG) is regulated by the ubiquitin–proteasomal system and is present in the pathological features of parkinsonian diseases |
title_fullStr |
Parkin Co-regulated Gene (PACRG) is regulated by the ubiquitin–proteasomal system and is present in the pathological features of parkinsonian diseases |
title_full_unstemmed |
Parkin Co-regulated Gene (PACRG) is regulated by the ubiquitin–proteasomal system and is present in the pathological features of parkinsonian diseases |
title_sort |
parkin co-regulated gene (pacrg) is regulated by the ubiquitin–proteasomal system and is present in the pathological features of parkinsonian diseases |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2007-08-01 |
description |
Mutations in parkin are a common cause of early-onset autosomal recessive Parkinson's disease. Parkin Co-Regulated Gene (PACRG) is a novel gene that was discovered because of its close genetic proximity to parkin and the two genes were subsequently demonstrated to be regulated by a bi-directional promoter. However the role of PACRG has not been well characterized and the distribution of the protein in both normal and diseased brain is not known. Here, we report that like parkin, PACRG is regulated by the ubiquitin–proteasomal system. Immunohistochemistry identified PACRG in astrocytes throughout the brain and in pigmented noradrenergic neurons of the locus coeruleus. PACRG was also detected in Lewy bodies and glial cytoplasmic inclusions in patients with Parkinson's disease and Multiple System Atrophy, respectively. Together, these results demonstrate that PACRG is regulated by the ubiquitin–proteasomal system and may play a role in the pathogenesis of Parkinson's disease. |
topic |
PACRG Parkin Ubiquitin–proteasomal system Lewy bodies |
url |
http://www.sciencedirect.com/science/article/pii/S0969996107001040 |
work_keys_str_mv |
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