Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells

Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells

Abstract Background Thrombospondin-1 (TSP-1), a Ca2+-binding trimeric glycoprotein secreted by multiple cell types, has been implicated in the pathophysiology of several clinical conditions. Signaling involving TSP-1, through its cognate receptor CD47, orchestrates a wide array of cellular functions...

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Bibliographic Details
Main Authors: Rosi Bissinger, Polina Petkova-Kirova, Olga Mykhailova, Per-Arne Oldenborg, Elena Novikova, David A. Donkor, Thomas Dietz, Abdulla Al Mamun Bhuyan, William P. Sheffield, Marijke Grau, Ferruh Artunc, Lars Kaestner, Jason P. Acker, Syed M. Qadri
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cell Communication and Signaling
Subjects:
Thrombospondin-1
CD47
Red blood cells
Calcium
Cation channels
Deformability
Online Access:http://link.springer.com/article/10.1186/s12964-020-00651-5

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