Consanguinity and clefts in the craniofacial region: A retrospective case-control study

• Main Authors: Betty Anna Jose, Subramani Arumugam Subramani, Varsha Mokhasi, Mini Jayan
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2015-01-01
• Series: Journal of Cleft Lip Palate and Craniofacial Anomalies
• Subjects: cleft; consanguinity; risk factor
• Online Access: http://www.jclpca.org/article.asp?issn=2348-2125;year=2015;volume=2;issue=2;spage=113;epage=117;aulast=Jose

Objective: The objective was to investigate the association between consanguinity and clefts in the craniofacial region. Materials and Methods: Sample consists of 179 non-syndromic cases of clefts in the craniofacial region and 200 healthy controls with no cleft or family history of clefting. A standardized questionnaire was prepared to investigate the information on the demographic characteristics and consanguinity. Chi-square and odds ratio were used to evaluate the risk of consanguinity in clefts in the craniofacial region. Results: There is a significant association between consanguinity and clefts (P = 0.001) when comparing the consanguinity and no consanguinity in cleft group and non-cleft group, and the association is more with the second degree consanguinity than the third degree consanguinity. Conclusion: Consanguinity is a risk factor for clefts in the craniofacial region.