8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one

8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 1 (NS2028) reacts with [2-chloro-5-(trifluoromethyl)phenyl]boronic acid 2 (2 equiv), Pd(OAc)2 (10 mol%) and KOAc (4 equiv) in acetonitrile heated to ca. 110 °C (sealed tube) for 12 hours to give 8-[2-chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4...

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Main Authors:	Andrey A. Berezin, Panayiotis A. Koutentis
Format:	Article
Language:	English
Published:	MDPI AG 2011-05-01
Series:	Molbank
Subjects:	soluble guanylyl cyclase inhibitors NS2028 benzoxazine oxadiazole Suzuki-Miyaura coupling
Online Access:	http://www.mdpi.com/1422-8599/2011/2/M728/

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spelling	doaj-708a10a3c597492aa16e0cb46f09b2752020-11-25T00:13:54ZengMDPI AGMolbank1422-85992011-05-0120112M72810.3390/M7288-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-oneAndrey A. BerezinPanayiotis A. Koutentis8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 1 (NS2028) reacts with [2-chloro-5-(trifluoromethyl)phenyl]boronic acid 2 (2 equiv), Pd(OAc)2 (10 mol%) and KOAc (4 equiv) in acetonitrile heated to ca. 110 °C (sealed tube) for 12 hours to give 8-[2-chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 4 in 64% yield.http://www.mdpi.com/1422-8599/2011/2/M728/soluble guanylyl cyclase inhibitorsNS2028benzoxazineoxadiazoleSuzuki-Miyaura coupling
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Andrey A. Berezin Panayiotis A. Koutentis
spellingShingle	Andrey A. Berezin Panayiotis A. Koutentis 8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one Molbank soluble guanylyl cyclase inhibitors NS2028 benzoxazine oxadiazole Suzuki-Miyaura coupling
author_facet	Andrey A. Berezin Panayiotis A. Koutentis
author_sort	Andrey A. Berezin
title	8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one
title_short	8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one
title_full	8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one
title_fullStr	8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one
title_full_unstemmed	8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one
title_sort	8-[2-chloro-5-(trifluoromethyl)phenyl]-4h-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one
publisher	MDPI AG
series	Molbank
issn	1422-8599
publishDate	2011-05-01
description	8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 1 (NS2028) reacts with [2-chloro-5-(trifluoromethyl)phenyl]boronic acid 2 (2 equiv), Pd(OAc)2 (10 mol%) and KOAc (4 equiv) in acetonitrile heated to ca. 110 °C (sealed tube) for 12 hours to give 8-[2-chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 4 in 64% yield.
topic	soluble guanylyl cyclase inhibitors NS2028 benzoxazine oxadiazole Suzuki-Miyaura coupling
url	http://www.mdpi.com/1422-8599/2011/2/M728/
work_keys_str_mv	AT andreyaberezin 82chloro5trifluoromethylphenyl4h124oxadiazolo34c14benzoxazin1one AT panayiotisakoutentis 82chloro5trifluoromethylphenyl4h124oxadiazolo34c14benzoxazin1one
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8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one

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