Mitoprotective Clinical Strategies in Type 2 Diabetes and Fanconi Anemia Patients: Suggestions for Clinical Management of Mitochondrial Dysfunction
Oxidative stress (OS) and mitochondrial dysfunction (MDF) occur in a number of disorders, and several clinical studies have attempted to counteract OS and MDF by providing adjuvant treatments against disease progression. The present review is aimed at focusing on two apparently distant diseases, nam...
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doaj-708de1b2e1f94285aaa5529127d222782020-11-25T01:10:11ZengMDPI AGAntioxidants2076-39212020-01-01918210.3390/antiox9010082antiox9010082Mitoprotective Clinical Strategies in Type 2 Diabetes and Fanconi Anemia Patients: Suggestions for Clinical Management of Mitochondrial DysfunctionGiovanni Pagano0Federico V. Pallardó1Beatriz Porto2Maria Rosa Fittipaldi3Alex Lyakhovich4Marco Trifuoggi5Department of Chemical Sciences, Federico II Naples University, I-80126 Naples, ItalyDepartment of Physiology, Faculty of Medicine and Dentistry, University of Valencia-INCLIVA, CIBERER, E-46010 Valencia, SpainInstitute of Biomedical Sciences, ICBAS, University of Porto, 4099-030 Porto, PortugalInternal Medicine Unit, San Francesco d’Assisi Hospital, I-84020 Oliveto Citra (SA), ItalyVall d’Hebron Institut de Recerca, E-08035 Barcelona, SpainDepartment of Chemical Sciences, Federico II Naples University, I-80126 Naples, ItalyOxidative stress (OS) and mitochondrial dysfunction (MDF) occur in a number of disorders, and several clinical studies have attempted to counteract OS and MDF by providing adjuvant treatments against disease progression. The present review is aimed at focusing on two apparently distant diseases, namely type 2 diabetes (T2D) and a rare genetic disease, Fanconi anemia (FA). The pathogenetic links between T2D and FA include the high T2D prevalence among FA patients and the recognized evidence for OS and MDF in both disorders. This latter phenotypic/pathogenetic feature—namely MDF—may be regarded as a mechanistic ground both accounting for the clinical outcomes in both diseases, and as a premise to clinical studies aimed at counteracting MDF. In the case for T2D, the working hypothesis is raised of evaluating any in vivo decrease of mitochondrial cofactors, or mitochondrial nutrients (MNs) such as α-lipoic acid, coenzyme Q10, and <span style="font-variant: small-caps;">l</span>-carnitine, with possibly combined MN-based treatments. As for FA, the established knowledge of MDF, as yet only obtained from in vitro or molecular studies, prompts the requirement to ascertain in vivo MDF, and to design clinical studies aimed at utilizing MNs toward mitigating or delaying FA’s clinical progression. Altogether, this paper may contribute to building hypotheses for clinical studies in a number of OS/MDF-related diseases.https://www.mdpi.com/2076-3921/9/1/82type 2 diabetesfanconi anemiaoxidative stressmitochondrial dysfunctionmitochondrial nutrients |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giovanni Pagano Federico V. Pallardó Beatriz Porto Maria Rosa Fittipaldi Alex Lyakhovich Marco Trifuoggi |
spellingShingle |
Giovanni Pagano Federico V. Pallardó Beatriz Porto Maria Rosa Fittipaldi Alex Lyakhovich Marco Trifuoggi Mitoprotective Clinical Strategies in Type 2 Diabetes and Fanconi Anemia Patients: Suggestions for Clinical Management of Mitochondrial Dysfunction Antioxidants type 2 diabetes fanconi anemia oxidative stress mitochondrial dysfunction mitochondrial nutrients |
author_facet |
Giovanni Pagano Federico V. Pallardó Beatriz Porto Maria Rosa Fittipaldi Alex Lyakhovich Marco Trifuoggi |
author_sort |
Giovanni Pagano |
title |
Mitoprotective Clinical Strategies in Type 2 Diabetes and Fanconi Anemia Patients: Suggestions for Clinical Management of Mitochondrial Dysfunction |
title_short |
Mitoprotective Clinical Strategies in Type 2 Diabetes and Fanconi Anemia Patients: Suggestions for Clinical Management of Mitochondrial Dysfunction |
title_full |
Mitoprotective Clinical Strategies in Type 2 Diabetes and Fanconi Anemia Patients: Suggestions for Clinical Management of Mitochondrial Dysfunction |
title_fullStr |
Mitoprotective Clinical Strategies in Type 2 Diabetes and Fanconi Anemia Patients: Suggestions for Clinical Management of Mitochondrial Dysfunction |
title_full_unstemmed |
Mitoprotective Clinical Strategies in Type 2 Diabetes and Fanconi Anemia Patients: Suggestions for Clinical Management of Mitochondrial Dysfunction |
title_sort |
mitoprotective clinical strategies in type 2 diabetes and fanconi anemia patients: suggestions for clinical management of mitochondrial dysfunction |
publisher |
MDPI AG |
series |
Antioxidants |
issn |
2076-3921 |
publishDate |
2020-01-01 |
description |
Oxidative stress (OS) and mitochondrial dysfunction (MDF) occur in a number of disorders, and several clinical studies have attempted to counteract OS and MDF by providing adjuvant treatments against disease progression. The present review is aimed at focusing on two apparently distant diseases, namely type 2 diabetes (T2D) and a rare genetic disease, Fanconi anemia (FA). The pathogenetic links between T2D and FA include the high T2D prevalence among FA patients and the recognized evidence for OS and MDF in both disorders. This latter phenotypic/pathogenetic feature—namely MDF—may be regarded as a mechanistic ground both accounting for the clinical outcomes in both diseases, and as a premise to clinical studies aimed at counteracting MDF. In the case for T2D, the working hypothesis is raised of evaluating any in vivo decrease of mitochondrial cofactors, or mitochondrial nutrients (MNs) such as α-lipoic acid, coenzyme Q10, and <span style="font-variant: small-caps;">l</span>-carnitine, with possibly combined MN-based treatments. As for FA, the established knowledge of MDF, as yet only obtained from in vitro or molecular studies, prompts the requirement to ascertain in vivo MDF, and to design clinical studies aimed at utilizing MNs toward mitigating or delaying FA’s clinical progression. Altogether, this paper may contribute to building hypotheses for clinical studies in a number of OS/MDF-related diseases. |
topic |
type 2 diabetes fanconi anemia oxidative stress mitochondrial dysfunction mitochondrial nutrients |
url |
https://www.mdpi.com/2076-3921/9/1/82 |
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