Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients

Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients

(1) Background: It is known that sickle cells contain a higher amount of Ca<sup>2+</sup> compared to healthy red blood cells (RBCs). The increased Ca<sup>2+</sup> is associated with the most severe symptom of sickle cell disease (SCD), the vaso-occlusive crisis (VOC). The Ca&...

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Bibliographic Details
Main Authors: Jue Wang, Laura Hertz, Sandra Ruppenthal, Wassim El Nemer, Philippe Connes, Jeroen S. Goede, Anna Bogdanova, Lutz Birnbaumer, Lars Kaestner
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
erythrocytes
sickle cell disease
LPA receptor
G protein signaling
transgenic mice
protein kinase Cα
Online Access:https://www.mdpi.com/2073-4409/10/2/456

Internet

https://www.mdpi.com/2073-4409/10/2/456

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