Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced t...

Full description

Bibliographic Details
Main Authors:	Guangshun Yang, Mingliang Ning, Bendong Chen
Format:	Article
Language:	English
Published:	MDPI AG 2012-04-01
Series:	Molecules
Subjects:	hepatocellular carcinoma paeonol oxidative injury immunity diethyl-nitrosamine
Online Access:	http://www.mdpi.com/1420-3049/17/4/4672

Similar Items

Fabrication, optimization, and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies
by: Kumar V, et al.
Published: (2017-09-01)

Cytokines as important playmakers of experimental hepatocarcinogenesis confounded by diabetes
by: Nabil M. Abdel-Hamid, et al.
Published: (2012-01-01)

Paeonol Inhibits Cell Proliferation, Migration and Invasion and Induces Apoptosis in Hepatocellular Carcinoma by Regulating miR-21-5p/KLF6 Axis
by: Cai M, et al.
Published: (2020-07-01)

Cationic Solid Lipid Nanoparticles of Resveratrol for Hepatocellular Carcinoma Treatment: Systematic Optimization, in vitro Characterization and Preclinical Investigation
by: Rahman M, et al.
Published: (2020-11-01)

Paeonol protects rat heart by improving regional blood perfusion during no-reflow
by: Lina Ma, et al.
Published: (2016-07-01)

Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague–Dawley rats
by: Nuria Roglans, et al.
Published: (2021-09-01)

Evaluation of LPS-Induced Acute Lung Injury Attenuation in Rats by Aminothiazole-Paeonol Derivatives
by: Pin-Kuei Fu, et al.
Published: (2017-09-01)

Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects
by: Chen C, et al.
Published: (2017-09-01)

Paeonol Improves Lipopolysaccharide-induced Microcirculatory Disturbance in Rat Mesentery
by: Lei Dong, et al.
Published: (2015-01-01)

Anticancer activity of Cynodon dactylon L. root extract against diethyl nitrosamine induced hepatic carcinoma
by: R Kowsalya, et al.
Published: (2015-01-01)

Paeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk
by: Chin-Feng Tsai, et al.
Published: (2021-01-01)

Pharmacokinetics, Tissue Distribution and Excretion of Paeonol and Its Major Metabolites in Rats Provide a Further Insight Into Paeonol Effectiveness
by: Xintong Hu, et al.
Published: (2020-02-01)

Paeonol Induces Protective Autophagy in Retinal Photoreceptor Cells
by: Daowei Zhang, et al.
Published: (2021-05-01)

Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt
by: Futian Xu, et al.
Published: (2019-03-01)

In Situ and in Vivo Study of Nasal Absorption of Paeonol in Rats
by: Pengyue Li, et al.
Published: (2010-11-01)

Synthesis and Evaluation of Aminothiazole-Paeonol Derivatives as Potential Anticancer Agents
by: Chia-Ying Tsai, et al.
Published: (2016-01-01)

Effects of Paeonol on Anti-Neuroinflammatory Responses in Microglial Cells
by: Chingju Lin, et al.
Published: (2015-04-01)

The Possible Contribution of P-Glycoprotein in the Protective Effect of Paeonol against Methotrexate-Induced Testicular Injury in Rats
by: Mohamed A. Morsy, et al.
Published: (2020-08-01)

Paeonol Attenuates Quorum-Sensing Regulated Virulence and Biofilm Formation in Pseudomonas aeruginosa
by: Dan Yang, et al.
Published: (2021-08-01)

Pharmacokinetics and Brain Distribution of the Active Components of DA-9805, Saikosaponin A, Paeonol, and Imperatorin in Rats
by: Mi Hye Kwon, et al.
Published: (2018-08-01)

Fluorimetric analysis of paeonol in Chinese herbal medicine Cynanchi Paniculati Radix by aluminum ion-sensitized fluorescence
by: Fei Yang, et al.
Published: (2012-06-01)

Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway
by: Chi-Ting Horng, et al.
Published: (2014-07-01)

Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson\'s Disease
by: Jamileh Ghalami, et al.
Published: (2021-01-01)

Effects of paeonol on proliferation and collagen synthesis of rat cardiac fibroblasts induced by aldosterone
by: Qian Xu, et al.
Published: (2021-04-01)

Paeonol-Loaded Ethosomes as Transdermal Delivery Carriers: Design, Preparation and Evaluation
by: Hongdan Ma, et al.
Published: (2018-07-01)

Biological Activities of Paeonol in Cardiovascular Diseases: A Review
by: Shalini Vellasamy, et al.
Published: (2021-08-01)

Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview
by: Min Wu, et al.
Published: (2021-07-01)

Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models
by: Hao Zhang, et al.
Published: (2020-04-01)

The paeonol target gene autophagy-related 5 has a potential therapeutic value in psoriasis treatment
by: Qian Zhang, et al.
Published: (2021-05-01)

Synthesis and Evaluation of Paeonol Derivatives as Potential Multifunctional Agents for the Treatment of Alzheimer’s Disease
by: An Zhou, et al.
Published: (2015-01-01)

Paeonol Attenuated Inflammatory Response of Endothelial Cells via Stimulating Monocytes-Derived Exosomal MicroRNA-223
by: Yarong Liu, et al.
Published: (2018-11-01)

Synthesis of Paeonol-Ozagrel Conjugate: Structure Characterization and In Vivo Anti-Ischemic Stroke potential
by: Jing Zhang, et al.
Published: (2021-02-01)

Comprehensive analysis of immune-related prognostic genes in the tumour microenvironment of hepatocellular carcinoma
by: Weike Gao, et al.
Published: (2021-03-01)

AGTRAP Is a Prognostic Biomarker Correlated With Immune Infiltration in Hepatocellular Carcinoma
by: Shanshan Liu, et al.
Published: (2021-09-01)

The Evolving Role of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma Treatment
by: Patrizia Leone, et al.
Published: (2021-05-01)

4-Methoxy Sulfonyl Paeonol Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis by Blocking the TGF-β1/Smad, PDGF-BB/MAPK and Akt Signaling Pathways
by: Yi-Jen Liao, et al.
Published: (2020-08-01)

Development and Verification of the Hypoxia-Related and Immune-Associated Prognosis Signature for Hepatocellular Carcinoma
by: Hu B, et al.
Published: (2020-11-01)

Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1
by: Lei Zhang, et al.
Published: (2018-05-01)

The Anti-atherosclerotic Effect of Paeonol against Vascular Smooth Muscle Cell Proliferation by Up-regulation of Autophagy via the AMPK/mTOR Signaling Pathway
by: Hongfei Wu, et al.
Published: (2018-01-01)

Chronic Supplementation of Paeonol Combined with Danshensu for the Improvement of Vascular Reactivity in the Cerebral Basilar Artery of Diabetic Rats
by: Peng-Cheng Qiu, et al.
Published: (2012-11-01)