Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery
Abstract Background Body composition assessment, measured using single‐slice computed tomography (CT) image at L3 level, and aerobic physical fitness, objectively measured using cardiopulmonary exercise testing (CPET), are each independently used for perioperative risk assessment. Sarcopenia (i.e. l...
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Wiley
2019-08-01
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Series: | Journal of Cachexia, Sarcopenia and Muscle |
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Online Access: | https://doi.org/10.1002/jcsm.12433 |
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doaj-70c241d8f3064f758f730230a57f3cda |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Malcolm A. West David P.J. vanDijk Fredrick Gleadowe Thomas Reeves John N. Primrose Mohammed Abu Hilal Mark R. Edwards Sandy Jack Sander S.S. Rensen Michael P.W. Grocott Denny Z.H. Levett Steven W.M. Olde Damink |
spellingShingle |
Malcolm A. West David P.J. vanDijk Fredrick Gleadowe Thomas Reeves John N. Primrose Mohammed Abu Hilal Mark R. Edwards Sandy Jack Sander S.S. Rensen Michael P.W. Grocott Denny Z.H. Levett Steven W.M. Olde Damink Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery Journal of Cachexia, Sarcopenia and Muscle Body composition Cardiopulmonary exercise testing Physical fitness Sarcopenia Myosteatosis Oxygen uptake |
author_facet |
Malcolm A. West David P.J. vanDijk Fredrick Gleadowe Thomas Reeves John N. Primrose Mohammed Abu Hilal Mark R. Edwards Sandy Jack Sander S.S. Rensen Michael P.W. Grocott Denny Z.H. Levett Steven W.M. Olde Damink |
author_sort |
Malcolm A. West |
title |
Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery |
title_short |
Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery |
title_full |
Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery |
title_fullStr |
Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery |
title_full_unstemmed |
Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery |
title_sort |
myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgery |
publisher |
Wiley |
series |
Journal of Cachexia, Sarcopenia and Muscle |
issn |
2190-5991 2190-6009 |
publishDate |
2019-08-01 |
description |
Abstract Background Body composition assessment, measured using single‐slice computed tomography (CT) image at L3 level, and aerobic physical fitness, objectively measured using cardiopulmonary exercise testing (CPET), are each independently used for perioperative risk assessment. Sarcopenia (i.e. low skeletal muscle mass), myosteatosis [i.e. low skeletal muscle radiation attenuation (SM‐RA)], and impaired objectively measured aerobic fitness (reduced oxygen uptake) have been associated with poor post‐operative outcomes and survival in various cancer types. However, the association between CT body composition and physical fitness has not been explored. In this study, we assessed the association of CT body composition with selected CPET variables in patients undergoing hepatobiliary and pancreatic surgery. Methods A pragmatic prospective cohort of 123 patients undergoing hepatobiliary and pancreatic surgery were recruited. All patients underwent preoperative CPET. Preoperative CT scans were analysed using a single‐slice CT image at L3 level to assess skeletal muscle mass, adipose tissue mass, and muscle radiation attenuation. Multivariate linear regression was used to test the association between CPET variables and body composition. Main outcomes were oxygen uptake at anaerobic threshold ( V̇O2 at AT), oxygen uptake at peak exercise ( V̇O2 peak), skeletal muscle mass, and SM‐RA. Results Of 123 patients recruited [77 men (63%), median age 66.9 ± 11.7, median body mass index 27.3 ± 5.2], 113 patients had good‐quality abdominal CT scans available and were included. Of the CT body composition variables, SM‐RA had the strongest correlation with V̇O2 peak (r = 0.57, P < 0.001) and V̇O2 at AT (r = 0.45, P < 0.001) while skeletal muscle mass was only weakly associated with V̇O2 peak (r = 0.24, P < 0.010). In the multivariate analysis, only SM‐RA was associated with V̇O2 peak (B = 0.25, 95% CI 0.15–0.34, P < 0.001, R2 = 0.42) and V̇O2 at AT (B = 0.13, 95% CI 0.06–0.18, P < 0.001, R2 = 0.26). Conclusions There is a positive association between preoperative CT SM‐RA and preoperative physical fitness ( V̇O2 at AT and at peak). This study demonstrates that myosteatosis, and not sarcopenia, is associated with reduced aerobic physical fitness. Combining both myosteatosis and physical fitness variables may provide additive risk stratification accuracy and guide interventions during the perioperative period. |
topic |
Body composition Cardiopulmonary exercise testing Physical fitness Sarcopenia Myosteatosis Oxygen uptake |
url |
https://doi.org/10.1002/jcsm.12433 |
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doaj-70c241d8f3064f758f730230a57f3cda2020-11-24T21:21:09ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092019-08-0110486087110.1002/jcsm.12433Myosteatosis is associated with poor physical fitness in patients undergoing hepatopancreatobiliary surgeryMalcolm A. West0David P.J. vanDijk1Fredrick Gleadowe2Thomas Reeves3John N. Primrose4Mohammed Abu Hilal5Mark R. Edwards6Sandy Jack7Sander S.S. Rensen8Michael P.W. Grocott9Denny Z.H. Levett10Steven W.M. Olde Damink11Academic Unit of Cancer Sciences, Faculty of Medicine University of Southampton Southampton UKDepartment of Surgery Maastricht University Medical Centre Maastricht The NetherlandsAcademic Unit of Cancer Sciences, Faculty of Medicine University of Southampton Southampton UKAcademic Unit of Cancer Sciences, Faculty of Medicine University of Southampton Southampton UKAcademic Unit of Cancer Sciences, Faculty of Medicine University of Southampton Southampton UKAcademic Unit of Cancer Sciences, Faculty of Medicine University of Southampton Southampton UKIntegrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine University of Southampton Southampton UKIntegrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine University of Southampton Southampton UKDepartment of Surgery Maastricht University Medical Centre Maastricht The NetherlandsIntegrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine University of Southampton Southampton UKIntegrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine University of Southampton Southampton UKDepartment of Surgery Maastricht University Medical Centre Maastricht The NetherlandsAbstract Background Body composition assessment, measured using single‐slice computed tomography (CT) image at L3 level, and aerobic physical fitness, objectively measured using cardiopulmonary exercise testing (CPET), are each independently used for perioperative risk assessment. Sarcopenia (i.e. low skeletal muscle mass), myosteatosis [i.e. low skeletal muscle radiation attenuation (SM‐RA)], and impaired objectively measured aerobic fitness (reduced oxygen uptake) have been associated with poor post‐operative outcomes and survival in various cancer types. However, the association between CT body composition and physical fitness has not been explored. In this study, we assessed the association of CT body composition with selected CPET variables in patients undergoing hepatobiliary and pancreatic surgery. Methods A pragmatic prospective cohort of 123 patients undergoing hepatobiliary and pancreatic surgery were recruited. All patients underwent preoperative CPET. Preoperative CT scans were analysed using a single‐slice CT image at L3 level to assess skeletal muscle mass, adipose tissue mass, and muscle radiation attenuation. Multivariate linear regression was used to test the association between CPET variables and body composition. Main outcomes were oxygen uptake at anaerobic threshold ( V̇O2 at AT), oxygen uptake at peak exercise ( V̇O2 peak), skeletal muscle mass, and SM‐RA. Results Of 123 patients recruited [77 men (63%), median age 66.9 ± 11.7, median body mass index 27.3 ± 5.2], 113 patients had good‐quality abdominal CT scans available and were included. Of the CT body composition variables, SM‐RA had the strongest correlation with V̇O2 peak (r = 0.57, P < 0.001) and V̇O2 at AT (r = 0.45, P < 0.001) while skeletal muscle mass was only weakly associated with V̇O2 peak (r = 0.24, P < 0.010). In the multivariate analysis, only SM‐RA was associated with V̇O2 peak (B = 0.25, 95% CI 0.15–0.34, P < 0.001, R2 = 0.42) and V̇O2 at AT (B = 0.13, 95% CI 0.06–0.18, P < 0.001, R2 = 0.26). Conclusions There is a positive association between preoperative CT SM‐RA and preoperative physical fitness ( V̇O2 at AT and at peak). This study demonstrates that myosteatosis, and not sarcopenia, is associated with reduced aerobic physical fitness. Combining both myosteatosis and physical fitness variables may provide additive risk stratification accuracy and guide interventions during the perioperative period.https://doi.org/10.1002/jcsm.12433Body compositionCardiopulmonary exercise testingPhysical fitnessSarcopeniaMyosteatosisOxygen uptake |