Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities
For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed, Scopus, and Google Scholar. The keywords of cucurbi...
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Tabriz University of Medical Sciences
2021-03-01
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doaj-70c7b40b55e243de937771a1c7ef15642021-03-30T08:59:25ZengTabriz University of Medical SciencesPharmaceutical Sciences2383-28862021-03-0127111310.34172/PS.2020.66ps-33569Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological ActivitiesMoazzameh Ramezani0Melika Hasani1Fatemeh Ramezani2Mahmood Karimi Abdolmaleki3Biology Department, Urmia University, Urmia, Iran.Sana Institute of Higher Education, Sari, Iran.Physiology Research Center, Iran University of Medical Science, Tehran, Iran.Department of Biology and Chemistry, Texas A&M International University, Laredo, TX 7808, USA.For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed, Scopus, and Google Scholar. The keywords of cucurbitacin, cucumber anticancer therapy, cytotoxic effects, chemotherapy, and inhibitor effect were searched until February 2020. According to the result of this review, cucurbitacin E as a tetracyclic triterpenes compound, has been exhibited cell cycle arrest, anti-inflammatory and anticancer activities. It showed tumor proliferation prevention, induction of apoptosis or synergistically acts with other established antitumor compounds and cytokines throughout many molecular mechanisms. In a function-structure association manner, cucurbitacin E can inhibit Janus kinas2 (JAK2) phosphorylation, the signal transducer activator of transcription 3 (STAT3) and subsequently block these pathways, which seems to be the main mechanism of its activity. Future studies could target its detection in uninvestigated sources, subsequently its derivatives to improve their anticancer activity.https://ps.tbzmed.ac.ir/PDF/ps-27-1-1.pdfcancerchemotherapycucurbitacinscytotoxic effectscucurbitacin e |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Moazzameh Ramezani Melika Hasani Fatemeh Ramezani Mahmood Karimi Abdolmaleki |
spellingShingle |
Moazzameh Ramezani Melika Hasani Fatemeh Ramezani Mahmood Karimi Abdolmaleki Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities Pharmaceutical Sciences cancer chemotherapy cucurbitacins cytotoxic effects cucurbitacin e |
author_facet |
Moazzameh Ramezani Melika Hasani Fatemeh Ramezani Mahmood Karimi Abdolmaleki |
author_sort |
Moazzameh Ramezani |
title |
Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities |
title_short |
Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities |
title_full |
Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities |
title_fullStr |
Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities |
title_full_unstemmed |
Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities |
title_sort |
cucurbitacins: a focus on cucurbitacin e as a natural product and their biological activities |
publisher |
Tabriz University of Medical Sciences |
series |
Pharmaceutical Sciences |
issn |
2383-2886 |
publishDate |
2021-03-01 |
description |
For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed, Scopus, and Google Scholar. The keywords of cucurbitacin, cucumber anticancer therapy, cytotoxic effects, chemotherapy, and inhibitor effect were searched until February 2020. According to the result of this review, cucurbitacin E as a tetracyclic triterpenes compound, has been exhibited cell cycle arrest, anti-inflammatory and anticancer activities. It showed tumor proliferation prevention, induction of apoptosis or synergistically acts with other established antitumor compounds and cytokines throughout many molecular mechanisms. In a function-structure association manner, cucurbitacin E can inhibit Janus kinas2 (JAK2) phosphorylation, the signal transducer activator of transcription 3 (STAT3) and subsequently block these pathways, which seems to be the main mechanism of its activity. Future studies could target its detection in uninvestigated sources, subsequently its derivatives to improve their anticancer activity. |
topic |
cancer chemotherapy cucurbitacins cytotoxic effects cucurbitacin e |
url |
https://ps.tbzmed.ac.ir/PDF/ps-27-1-1.pdf |
work_keys_str_mv |
AT moazzamehramezani cucurbitacinsafocusoncucurbitacineasanaturalproductandtheirbiologicalactivities AT melikahasani cucurbitacinsafocusoncucurbitacineasanaturalproductandtheirbiologicalactivities AT fatemehramezani cucurbitacinsafocusoncucurbitacineasanaturalproductandtheirbiologicalactivities AT mahmoodkarimiabdolmaleki cucurbitacinsafocusoncucurbitacineasanaturalproductandtheirbiologicalactivities |
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