SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. describe an additional SUMOylation at residue K595, w...
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Bibliographic Details
Main Authors: |
Charlotte Martinat,
Arthur Cormier,
Joëlle Tobaly-Tapiero,
Noé Palmic,
Nicoletta Casartelli,
Bijan Mahboubi,
Si’Ana A. Coggins,
Julian Buchrieser,
Mirjana Persaud,
Felipe Diaz-Griffero,
Lucile Espert,
Guillaume Bossis,
Pascale Lesage,
Olivier Schwartz,
Baek Kim,
Florence Margottin-Goguet,
Ali Saïb,
Alessia Zamborlini |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2021-07-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-021-24802-5
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