SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells

SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. describe an additional SUMOylation at residue K595, w...

Full description

Bibliographic Details
Main Authors:	Charlotte Martinat, Arthur Cormier, Joëlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Bijan Mahboubi, Si’Ana A. Coggins, Julian Buchrieser, Mirjana Persaud, Felipe Diaz-Griffero, Lucile Espert, Guillaume Bossis, Pascale Lesage, Olivier Schwartz, Baek Kim, Florence Margottin-Goguet, Ali Saïb, Alessia Zamborlini
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-24802-5

id	doaj-70d02ba8c29446d69d93dada293f5c11
record_format	Article
spelling	doaj-70d02ba8c29446d69d93dada293f5c112021-08-01T11:38:46ZengNature Publishing GroupNature Communications2041-17232021-07-0112111510.1038/s41467-021-24802-5SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cellsCharlotte Martinat0Arthur Cormier1Joëlle Tobaly-Tapiero2Noé Palmic3Nicoletta Casartelli4Bijan Mahboubi5Si’Ana A. Coggins6Julian Buchrieser7Mirjana Persaud8Felipe Diaz-Griffero9Lucile Espert10Guillaume Bossis11Pascale Lesage12Olivier Schwartz13Baek Kim14Florence Margottin-Goguet15Ali Saïb16Alessia Zamborlini17INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-LouisINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-LouisINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-LouisINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-LouisInstitut Pasteur, Virus and Immunity Unit, CNRS-UMR3569Emory School of MedicineEmory School of MedicineInstitut Pasteur, Virus and Immunity Unit, CNRS-UMR3569Albert Einstein College of Medicine, Microbiology and ImmunologyAlbert Einstein College of Medicine, Microbiology and ImmunologyIRIM, University of Montpellier, UMR 9004 CNRSIGMM, Univ Montpellier, CNRSINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-LouisInstitut Pasteur, Virus and Immunity Unit, CNRS-UMR3569Emory School of MedicineUniversité de Paris, Institut Cochin, INSERM, CNRSINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-LouisINSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-LouisSAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. describe an additional SUMOylation at residue K595, which promotes the dNTPase-independent restriction activity.https://doi.org/10.1038/s41467-021-24802-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Charlotte Martinat Arthur Cormier Joëlle Tobaly-Tapiero Noé Palmic Nicoletta Casartelli Bijan Mahboubi Si’Ana A. Coggins Julian Buchrieser Mirjana Persaud Felipe Diaz-Griffero Lucile Espert Guillaume Bossis Pascale Lesage Olivier Schwartz Baek Kim Florence Margottin-Goguet Ali Saïb Alessia Zamborlini
spellingShingle	Charlotte Martinat Arthur Cormier Joëlle Tobaly-Tapiero Noé Palmic Nicoletta Casartelli Bijan Mahboubi Si’Ana A. Coggins Julian Buchrieser Mirjana Persaud Felipe Diaz-Griffero Lucile Espert Guillaume Bossis Pascale Lesage Olivier Schwartz Baek Kim Florence Margottin-Goguet Ali Saïb Alessia Zamborlini SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells Nature Communications
author_facet	Charlotte Martinat Arthur Cormier Joëlle Tobaly-Tapiero Noé Palmic Nicoletta Casartelli Bijan Mahboubi Si’Ana A. Coggins Julian Buchrieser Mirjana Persaud Felipe Diaz-Griffero Lucile Espert Guillaume Bossis Pascale Lesage Olivier Schwartz Baek Kim Florence Margottin-Goguet Ali Saïb Alessia Zamborlini
author_sort	Charlotte Martinat
title	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
title_short	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
title_full	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
title_fullStr	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
title_full_unstemmed	SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
title_sort	sumoylation of samhd1 at lysine 595 is required for hiv-1 restriction in non-cycling cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-07-01
description	SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. describe an additional SUMOylation at residue K595, which promotes the dNTPase-independent restriction activity.
url	https://doi.org/10.1038/s41467-021-24802-5
work_keys_str_mv	AT charlottemartinat sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT arthurcormier sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT joelletobalytapiero sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT noepalmic sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT nicolettacasartelli sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT bijanmahboubi sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT sianaacoggins sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT julianbuchrieser sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT mirjanapersaud sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT felipediazgriffero sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT lucileespert sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT guillaumebossis sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT pascalelesage sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT olivierschwartz sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT baekkim sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT florencemargottingoguet sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT alisaib sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells AT alessiazamborlini sumoylationofsamhd1atlysine595isrequiredforhiv1restrictioninnoncyclingcells
_version_	1721245675162697728

SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells

Similar Items