Biologic Complexity in Sickle Cell Disease: Implications for Developing Targeted Therapeutics

Biologic Complexity in Sickle Cell Disease: Implications for Developing Targeted Therapeutics

Current therapy for sickle cell disease (SCD) is limited to supportive treatment of complications, red blood cell transfusions, hydroxyurea, and stem cell transplantation. Difficulty in the translation of mechanistically based therapies may be the result of a reductionist approach focused on individ...

Full description

Bibliographic Details
Main Author:	Beatrice E. Gee
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1155/2013/694146

Similar Items

The Role of Nutrition in Sickle Cell Disease
by: H.I. Hyacinth, et al.
Published: (2010-01-01)

The Role of Nutrition in Sickle Cell Disease
by: H.I. Hyacinth, et al.
Published: (2010-10-01)

Asthma in Sickle Cell Disease: Implications for Treatment
by: Kathryn Blake, et al.
Published: (2011-01-01)

NEW THERAPEUTIC OPTIONS FOR THE TREATMENT OF SICKLE CELL DISEASE
by: Alessandro Matte, et al.
Published: (2019-01-01)

Potential therapeutic action of nitrite in sickle cell disease
by: Nadeem Wajih, et al.
Published: (2017-08-01)

Therapeutic advances in sickle cell disease in the last decade
by: Arun S Shet, et al.
Published: (2017-01-01)

Genetic and biological markers of severity in sickle cell disease
by: Drasar, Emma Rachel
Published: (2014)

The role of the arginine metabolome in pain: implications for sickle cell disease
by: Bakshi N, et al.
Published: (2016-03-01)

The molecular biology of sickle cell anaemia
by: Shannon, Matthew Frederick
Published: (2018)

Sickle Cell Diseases
by: Mehmet Helvaci
Published: (2015-07-01)

Phytomedicines and Nutraceuticals: Alternative Therapeutics for Sickle Cell Anemia
by: Ngozi Awa Imaga
Published: (2013-01-01)

Sexuality and sickle cell disease
by: Maria Stella Figueiredo
Published: (2013-01-01)

Sexuality and sickle cell disease
by: Maria Stella Figueiredo
Published: (2013-01-01)

Sickle cell disease complications
by: Ersi Voskaridou
Published: (2014-12-01)

Sickle Cell Disease and HIV
by: Esther Brenda Odera MBChB, et al.
Published: (2014-03-01)

Headache in Sickle Cell Disease
by: J Gordon Millichap
Published: (2007-08-01)

Sickle cell disease in pregnancy
by: Neelima T, et al.
Published: (2016-02-01)

Asthma in Sickle Cell Disease
by: Manisha Newaskar, et al.
Published: (2011-01-01)

SICKLE CELL DISEASE AND PREGNANCY
by: Dipty Jain, et al.
Published: (2019-06-01)

Development of pulmonary function abnormalities in sickle cell disease
by: Lunt, Alan Charles
Published: (2017)

Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
by: Obianuju B Ozoh, et al.
Published: (2019-01-01)

Implications of aneuploidy for stem cell biology and brain therapeutics
by: Sylvie eDevalle, et al.
Published: (2012-09-01)

Newborn Screening for Sickle Cell Disease in Europe
by: Yvonne Daniel, et al.
Published: (2019-02-01)

Sickle Cell Anemia, the First Molecular Disease: Overview of Molecular Etiology, Pathophysiology, and Therapeutic Approaches
by: Martin H. Steinberg
Published: (2008-01-01)

Clonal hematopoiesis in sickle cell disease
by: Abecasis, G.R, et al.
Published: (2022)

Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
by: Mahmood Dhahir Al-Mendalawi
Published: (2020-01-01)

Relationship between pulmonary and cardiac abnormalities in sickle cell disease: implications for the management of patients
by: Maria Christina Paixão Maioli, et al.
Published: (2016-02-01)

Low nitric oxide level is implicated in sickle cell disease and its complications in Ghana
by: Antwi-Boasiako C, et al.
Published: (2018-09-01)

Clinical Implications of the Association of Fetal Hemoglobin with Peripheral Oxygen Saturation in Sickle Cell Disease
by: Osheiza Abdulmalik, et al.
Published: (2017-10-01)

Prevalence of sickle cell disease and sickle cell trait in national neonatal screening studies
by: Luciana Garcia Lervolino, et al.
Published: (2011-02-01)

Trauma and Stem Cells: Biology and Potential Therapeutic Implications
by: Kabilan Thurairajah, et al.
Published: (2017-03-01)

Glioblastoma Stem-Like Cells—Biology and Therapeutic Implications
by: John A. Boockvar, et al.
Published: (2011-06-01)

Cancer Stem Cells and Their Microenvironment: Biology and Therapeutic Implications
by: Eunice Yuen-Ting Lau, et al.
Published: (2017-01-01)

Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis
by: Du, E, et al.
Published: (2015)

Effect of sickle cell crises on glomerular filtration rate in children with sickle cell disease in Ilorin, Nigeria
by: E A Anigilaje, et al.
Published: (2013-01-01)

Development of a Severity Classification System for Sickle Cell Disease
by: Shah N, et al.
Published: (2020-10-01)

Sickle Cell Disease: Management options and challenges in developing countries
by: Daniel Ansong, et al.
Published: (2013-11-01)

Oxidative stress in sickle cell disease
by: Raphael Ferreira Queiroz, et al.
Published: (2013-01-01)

Asthma Management in Sickle Cell Disease
by: Esteban Gomez, et al.
Published: (2013-01-01)

Gangrene and sepsis in sickle cell disease
by: Umma Abdulsalam Ibrahim, et al.
Published: (2020-01-01)

Cannot write session to /tmp/vufind_sessions/sess_i2io065nrfj6pehnt748r273r2