The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium.
Salmonella enterica Serovar Typhimurium (S. Typhimurium) is an intracellular bacterium that overcomes host immune system barriers for successful infection. The bacterium colonizes the proximal small intestine, penetrates the epithelial layer, and is engulfed by macrophages and neutrophils. Intracell...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC6122832?pdf=render |
id |
doaj-70f292dcf0724771a698bdbeb293d65f |
---|---|
record_format |
Article |
spelling |
doaj-70f292dcf0724771a698bdbeb293d65f2020-11-25T01:17:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01139e020349710.1371/journal.pone.0203497The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium.Coral Pardo-EstéAlejandro A HidalgoCamila AguirreAlan C BrionesCarolina E CabezasJuan Castro-SeverynJuan A FuentesCecilia M OpazoClaudia A RiedelCarolina OteroRodrigo PachecoMiguel A ValvanoClaudia P SaavedraSalmonella enterica Serovar Typhimurium (S. Typhimurium) is an intracellular bacterium that overcomes host immune system barriers for successful infection. The bacterium colonizes the proximal small intestine, penetrates the epithelial layer, and is engulfed by macrophages and neutrophils. Intracellularly, S. Typhimurium encounters highly toxic reactive oxygen species including hydrogen peroxide and hypochlorous acid. The molecular mechanisms of Salmonella resistance to intracellular oxidative stress is not completely understood. The ArcAB two-component system is a global regulatory system that responds to oxygen. In this work, we show that the ArcA response regulator participates in Salmonella adaptation to changing oxygen levels and is also involved in promoting intracellular survival in macrophages and neutrophils, enabling S. Typhimurium to successfully establish a systemic infection.http://europepmc.org/articles/PMC6122832?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Coral Pardo-Esté Alejandro A Hidalgo Camila Aguirre Alan C Briones Carolina E Cabezas Juan Castro-Severyn Juan A Fuentes Cecilia M Opazo Claudia A Riedel Carolina Otero Rodrigo Pacheco Miguel A Valvano Claudia P Saavedra |
spellingShingle |
Coral Pardo-Esté Alejandro A Hidalgo Camila Aguirre Alan C Briones Carolina E Cabezas Juan Castro-Severyn Juan A Fuentes Cecilia M Opazo Claudia A Riedel Carolina Otero Rodrigo Pacheco Miguel A Valvano Claudia P Saavedra The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium. PLoS ONE |
author_facet |
Coral Pardo-Esté Alejandro A Hidalgo Camila Aguirre Alan C Briones Carolina E Cabezas Juan Castro-Severyn Juan A Fuentes Cecilia M Opazo Claudia A Riedel Carolina Otero Rodrigo Pacheco Miguel A Valvano Claudia P Saavedra |
author_sort |
Coral Pardo-Esté |
title |
The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium. |
title_short |
The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium. |
title_full |
The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium. |
title_fullStr |
The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium. |
title_full_unstemmed |
The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium. |
title_sort |
arcab two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by salmonella typhimurium. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
Salmonella enterica Serovar Typhimurium (S. Typhimurium) is an intracellular bacterium that overcomes host immune system barriers for successful infection. The bacterium colonizes the proximal small intestine, penetrates the epithelial layer, and is engulfed by macrophages and neutrophils. Intracellularly, S. Typhimurium encounters highly toxic reactive oxygen species including hydrogen peroxide and hypochlorous acid. The molecular mechanisms of Salmonella resistance to intracellular oxidative stress is not completely understood. The ArcAB two-component system is a global regulatory system that responds to oxygen. In this work, we show that the ArcA response regulator participates in Salmonella adaptation to changing oxygen levels and is also involved in promoting intracellular survival in macrophages and neutrophils, enabling S. Typhimurium to successfully establish a systemic infection. |
url |
http://europepmc.org/articles/PMC6122832?pdf=render |
work_keys_str_mv |
AT coralpardoeste thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT alejandroahidalgo thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT camilaaguirre thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT alancbriones thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT carolinaecabezas thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT juancastroseveryn thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT juanafuentes thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT ceciliamopazo thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT claudiaariedel thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT carolinaotero thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT rodrigopacheco thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT miguelavalvano thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT claudiapsaavedra thearcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT coralpardoeste arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT alejandroahidalgo arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT camilaaguirre arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT alancbriones arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT carolinaecabezas arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT juancastroseveryn arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT juanafuentes arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT ceciliamopazo arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT claudiaariedel arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT carolinaotero arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT rodrigopacheco arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT miguelavalvano arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium AT claudiapsaavedra arcabtwocomponentregulatorysystempromotesresistancetoreactiveoxygenspeciesandsystemicinfectionbysalmonellatyphimurium |
_version_ |
1725147657220915200 |