ABO, Rhesus Blood Groups and Transfusion-transmitted Infections among Blood Donors in Gabon
Background: Few studies focused on the study of blood groups in Gabon. This study aimed to determine the phenotypic frequency of ABO and Rhesus antigens in blood donors of Libreville and to assess the association between ABO blood groups and transfusion-transmitted infections. Materials and Methods:...
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doaj-70f89764b9da4148969b4d7a3f42a7a72021-08-02T23:44:01ZengKnowledge ESudan Journal of Medical Sciences1858-50512018-03-011311010.18502/sjms.v13i1.1685sjms.v13i1.1685ABO, Rhesus Blood Groups and Transfusion-transmitted Infections among Blood Donors in GabonChrist-Dominique Ngassaki-Yoka0Jophrette Mireille Ntsame Ndong1Cyrille Bisseye2 National Blood Transfusion Center, P.O. Box 13895, Libreville, Gabon National Blood Transfusion Center, P.O. Box 13895, Libreville, Gabon National Blood Transfusion Center, P.O. Box 13895, Libreville, GabonBackground: Few studies focused on the study of blood groups in Gabon. This study aimed to determine the phenotypic frequency of ABO and Rhesus antigens in blood donors of Libreville and to assess the association between ABO blood groups and transfusion-transmitted infections. Materials and Methods: The study of ABO and Rhesus blood groups concerned 4,744 blood donors. ABO and Rhesus phenotyping were obtained using monoclonal monospecific antisera: anti-A, anti-B, anti-AB, anti-D, anti-E, anti-C, anti-c, and anti-e with an automate (QWALYSⓇ 3, DIAGAST, France) or a card gel (ID Card, BIO-RAD) according to manufacturer's instructions. Results: The phenotypic frequency of blood group antigens A, B, AB and O were respectively 21.0%; 17.6%; 2.6% and 58.9%. Those of Rhesus antigens D, d, C, c, E and e were 97.7%; 2.3%; 15.9%; 99.9%; 17.6%; 99.3%, respectively. The prevalence of ABO and Rh antigens in Gabonese donors reported here are significantly different from those of neighboring countries. No association was found between the prevalence of HIV, HCV and syphilis and ABO blood groups. Instead, HBV seroprevalence was twice as high among non-O blood groups donors compared with blood group O donors [OR = 2 (CI 1.26 to 3.2), p = 0.003]. Conclusions: This study provides new data on phenotypic frequency of ABO and Rh blood groups in a representative sample of the Gabonese blood donor population. It suggests a significant association between ABO blood group and HBV infection.https://doi.org/10.18502/sjms.v13i1.1685ABO, Rhesus, blood donors, HBV, Gabon |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christ-Dominique Ngassaki-Yoka Jophrette Mireille Ntsame Ndong Cyrille Bisseye |
spellingShingle |
Christ-Dominique Ngassaki-Yoka Jophrette Mireille Ntsame Ndong Cyrille Bisseye ABO, Rhesus Blood Groups and Transfusion-transmitted Infections among Blood Donors in Gabon Sudan Journal of Medical Sciences ABO, Rhesus, blood donors, HBV, Gabon |
author_facet |
Christ-Dominique Ngassaki-Yoka Jophrette Mireille Ntsame Ndong Cyrille Bisseye |
author_sort |
Christ-Dominique Ngassaki-Yoka |
title |
ABO, Rhesus Blood Groups and Transfusion-transmitted Infections among Blood Donors in Gabon |
title_short |
ABO, Rhesus Blood Groups and Transfusion-transmitted Infections among Blood Donors in Gabon |
title_full |
ABO, Rhesus Blood Groups and Transfusion-transmitted Infections among Blood Donors in Gabon |
title_fullStr |
ABO, Rhesus Blood Groups and Transfusion-transmitted Infections among Blood Donors in Gabon |
title_full_unstemmed |
ABO, Rhesus Blood Groups and Transfusion-transmitted Infections among Blood Donors in Gabon |
title_sort |
abo, rhesus blood groups and transfusion-transmitted infections among blood donors in gabon |
publisher |
Knowledge E |
series |
Sudan Journal of Medical Sciences |
issn |
1858-5051 |
publishDate |
2018-03-01 |
description |
Background: Few studies focused on the study of blood groups in Gabon. This study aimed to determine the phenotypic frequency of ABO and Rhesus antigens in blood donors of Libreville and to assess the association between ABO blood groups and transfusion-transmitted infections.
Materials and Methods: The study of ABO and Rhesus blood groups concerned 4,744 blood donors. ABO and Rhesus phenotyping were obtained using monoclonal monospecific antisera: anti-A, anti-B, anti-AB, anti-D, anti-E, anti-C, anti-c, and anti-e with an automate (QWALYSⓇ 3, DIAGAST, France) or a card gel (ID Card, BIO-RAD) according to manufacturer's instructions.
Results: The phenotypic frequency of blood group antigens A, B, AB and O were respectively 21.0%; 17.6%; 2.6% and 58.9%. Those of Rhesus antigens D, d, C, c, E and e were 97.7%; 2.3%; 15.9%; 99.9%; 17.6%; 99.3%, respectively. The prevalence of ABO and Rh antigens in Gabonese donors reported here are significantly different from those of neighboring countries. No association was found between the prevalence of HIV, HCV and syphilis and ABO blood groups. Instead, HBV seroprevalence was twice as high among non-O blood groups donors compared with blood group O donors [OR = 2 (CI 1.26 to 3.2), p = 0.003].
Conclusions: This study provides new data on phenotypic frequency of ABO and Rh blood groups in a representative sample of the Gabonese blood donor population. It suggests a significant association between ABO blood group and HBV infection. |
topic |
ABO, Rhesus, blood donors, HBV, Gabon |
url |
https://doi.org/10.18502/sjms.v13i1.1685 |
work_keys_str_mv |
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