Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea
Rosacea is a skin inflammatory condition that is accompanied by not only redness and flushing but also unseen symptoms, such as burning, stinging, and itching. TRPV1 expression in UVB-exposed skin can lead to a painful burning sensation. Upregulated TRPV1 expression helps release neuropeptides, incl...
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2021-03-01
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doaj-70fb81bfe7a1454e8cc70e34f75e1b5e2021-03-07T00:00:25ZengMDPI AGMolecules1420-30492021-03-01261424142410.3390/molecules26051424Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in RosaceaSeyeon Oh0Myeongjoo Son1Joonhong Park2Donghwan Kang3Kyunghee Byun4Functional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon 21999, KoreaFunctional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon 21999, KoreaMaymorning Dermatologic Clinic, Sungnam 13306, KoreaJeisys Medical Inc., Seoul 08501, KoreaFunctional Cellular Networks Laboratory, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon 21999, KoreaRosacea is a skin inflammatory condition that is accompanied by not only redness and flushing but also unseen symptoms, such as burning, stinging, and itching. TRPV1 expression in UVB-exposed skin can lead to a painful burning sensation. Upregulated TRPV1 expression helps release neuropeptides, including calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide, and vasoactive intestinal peptide, which can activate macrophage and inflammatory molecules. In this study, we found that radiofrequency (RF) irradiation reduced TRPV1 activation and neuropeptide expression in a UVB-exposed in vivo model and UVB- or heat-treated in an in vitro model. RF irradiation attenuated neuropeptide-induced macrophage activation and inflammatory molecule expression. Interestingly, the burning sensation in the skin of UVB-exposed mice and patients with rosacea was significantly decreased by RF irradiation. These results can provide experimental and molecular evidence on the effective use of RF irradiation for the burning sensation in patients with rosacea.https://www.mdpi.com/1420-3049/26/5/1424rosaceaburning sensationmicroneedling radiofrequencyTRPV1neuropeptides |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seyeon Oh Myeongjoo Son Joonhong Park Donghwan Kang Kyunghee Byun |
spellingShingle |
Seyeon Oh Myeongjoo Son Joonhong Park Donghwan Kang Kyunghee Byun Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea Molecules rosacea burning sensation microneedling radiofrequency TRPV1 neuropeptides |
author_facet |
Seyeon Oh Myeongjoo Son Joonhong Park Donghwan Kang Kyunghee Byun |
author_sort |
Seyeon Oh |
title |
Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea |
title_short |
Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea |
title_full |
Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea |
title_fullStr |
Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea |
title_full_unstemmed |
Radiofrequency Irradiation Modulates TRPV1-Related Burning Sensation in Rosacea |
title_sort |
radiofrequency irradiation modulates trpv1-related burning sensation in rosacea |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2021-03-01 |
description |
Rosacea is a skin inflammatory condition that is accompanied by not only redness and flushing but also unseen symptoms, such as burning, stinging, and itching. TRPV1 expression in UVB-exposed skin can lead to a painful burning sensation. Upregulated TRPV1 expression helps release neuropeptides, including calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide, and vasoactive intestinal peptide, which can activate macrophage and inflammatory molecules. In this study, we found that radiofrequency (RF) irradiation reduced TRPV1 activation and neuropeptide expression in a UVB-exposed in vivo model and UVB- or heat-treated in an in vitro model. RF irradiation attenuated neuropeptide-induced macrophage activation and inflammatory molecule expression. Interestingly, the burning sensation in the skin of UVB-exposed mice and patients with rosacea was significantly decreased by RF irradiation. These results can provide experimental and molecular evidence on the effective use of RF irradiation for the burning sensation in patients with rosacea. |
topic |
rosacea burning sensation microneedling radiofrequency TRPV1 neuropeptides |
url |
https://www.mdpi.com/1420-3049/26/5/1424 |
work_keys_str_mv |
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