Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

Tumor escape to immunosurveillance and resistance to immune attacks present a major hurdle in cancer therapy, especially in the current era of new cancer immunotherapies. We report here that hypoxia, a hallmark of most solid tumors, orchestrates carcinoma cell heterogeneity through the induction of...

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Bibliographic Details
Main Authors: Stéphane Terry, Stéphanie Buart, Tuan Zea Tan, Gwendoline Gros, Muhammad Zaeem Noman, James B. Lorens, Fathia Mami-Chouaib, Jean Paul Thiery, Salem Chouaib
Format: Article
Language:English
Published: Taylor & Francis Group 2017-02-01
Series:OncoImmunology
Subjects:
antitumor cytotoxic response
ctl
emt
hypoxia
hif
nsclc
nk cells
tgf-β
Online Access:http://dx.doi.org/10.1080/2162402X.2016.1271858

Internet

http://dx.doi.org/10.1080/2162402X.2016.1271858

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