Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity

Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity

Group 2 innate lymphoid cells (ILC2) have emerged as a major component of type 2 inflammation in mice and humans. ILC2 secrete large amounts of interleukins 5 and 13, which are largely responsible for host protective immunity against helminth parasites because these cytokines induce profound changes...

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Bibliographic Details
Main Authors: De’Broski R. Herbert, Bonnie Douglas, Kelly Zullo
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
helminth
mucosa
type 2 immunity
innate lymphocyte
Online Access:https://www.mdpi.com/1422-0067/20/9/2276
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spelling doaj-70fc8b479290430eb1ccb9718a5da65a2020-11-25T02:07:04ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-05-01209227610.3390/ijms20092276ijms20092276Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth ImmunityDe’Broski R. Herbert0Bonnie Douglas1Kelly Zullo2School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USASchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USASchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USAGroup 2 innate lymphoid cells (ILC2) have emerged as a major component of type 2 inflammation in mice and humans. ILC2 secrete large amounts of interleukins 5 and 13, which are largely responsible for host protective immunity against helminth parasites because these cytokines induce profound changes in host physiology that include: goblet cell metaplasia, mucus accumulation, smooth muscle hypercontractility, eosinophil and mast cell recruitment, and alternative macrophage activation (M2). This review covers the initial recognition of ILC2 as a distinct cell lineage, the key studies that established their biological importance, particularly in helminth infection, and the new directions that are likely to be the focus of emerging work that further explores this unique cell population in the context of health and disease.https://www.mdpi.com/1422-0067/20/9/2276helminthmucosatype 2 immunityinnate lymphocyte
collection DOAJ
language English
format Article
sources DOAJ
author De’Broski R. Herbert
Bonnie Douglas
Kelly Zullo
spellingShingle De’Broski R. Herbert
Bonnie Douglas
Kelly Zullo
Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity
International Journal of Molecular Sciences
helminth
mucosa
type 2 immunity
innate lymphocyte
author_facet De’Broski R. Herbert
Bonnie Douglas
Kelly Zullo
author_sort De’Broski R. Herbert
title Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity
title_short Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity
title_full Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity
title_fullStr Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity
title_full_unstemmed Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity
title_sort group 2 innate lymphoid cells (ilc2): type 2 immunity and helminth immunity
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2019-05-01
description Group 2 innate lymphoid cells (ILC2) have emerged as a major component of type 2 inflammation in mice and humans. ILC2 secrete large amounts of interleukins 5 and 13, which are largely responsible for host protective immunity against helminth parasites because these cytokines induce profound changes in host physiology that include: goblet cell metaplasia, mucus accumulation, smooth muscle hypercontractility, eosinophil and mast cell recruitment, and alternative macrophage activation (M2). This review covers the initial recognition of ILC2 as a distinct cell lineage, the key studies that established their biological importance, particularly in helminth infection, and the new directions that are likely to be the focus of emerging work that further explores this unique cell population in the context of health and disease.
topic helminth
mucosa
type 2 immunity
innate lymphocyte
url https://www.mdpi.com/1422-0067/20/9/2276
work_keys_str_mv AT debroskirherbert group2innatelymphoidcellsilc2type2immunityandhelminthimmunity
AT bonniedouglas group2innatelymphoidcellsilc2type2immunityandhelminthimmunity
AT kellyzullo group2innatelymphoidcellsilc2type2immunityandhelminthimmunity
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