Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group
Abstract The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, h...
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Format: | Article |
Language: | English |
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BMC
2018-06-01
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Series: | Malaria Journal |
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Online Access: | http://link.springer.com/article/10.1186/s12936-018-2380-8 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kamala Thriemer Albino Bobogare Benedikt Ley Clarice Samo Gudo Mohammad Shafiul Alam Nick M. Anstey Elizabeth Ashley J. Kevin Baird Charlotte Gryseels Elodie Jambert Marcus Lacerda Ferdinand Laihad Jutta Marfurt Ayodhia Pitaloka Pasaribu Jeanne Rini Poespoprodjo Inge Sutanto Walter R. Taylor Christel van den Boogaard Katherine E. Battle Lek Dysoley Prakash Ghimire Bill Hawley Jimee Hwang Wasif Ali Khan Rose Nani Binti Mudin Maria Endang Sumiwi Rukhsana Ahmed M. M. Aktaruzzaman Kiran Raj Awasthi Azucena Bardaji David Bell Leonard Boaz Faustina Helen Burdam Daniel Chandramohan Qin Cheng Keobouphaphone Chindawongsa Janice Culpepper Santasabuj Das Raffy Deray Meghna Desai Gonzalo Domingo Wang Duoquan Stephan Duparc Rustini Floranita Emily Gerth-Guyette Rosalind E. Howes Cecilia Hugo George Jagoe Elvieda Sariwati Sanya Tahmina Jhora Wu Jinwei Harin Karunajeewa Enny Kenangalem Bibek Kumar Lal Chandra Landuwulang Emmanuel Le Perru Sang-Eun Lee Leo Sora Makita James McCarthy Asrat Mekuria Neelima Mishra Esau Naket Simone Nambanya Johnny Nausien Thang Ngo Duc Thuan Nguyen Thi Rinitis Noviyanti Daniel Pfeffer Gao Qi Annisa Rahmalia Stephen Rogerson Iriani Samad Jetsumon Sattabongkot Ari Satyagraha Dennis Shanks Surender Nath Sharma Carol Hopkins Sibley Ali Sungkar Din Syafruddin Arunansu Talukdar Joel Tarning Feiko ter Kuile Suman Thapa Minerva Theodora Tho Tran Huy Edward Waramin Govert Waramori Adugna Woyessa Chansuda Wongsrichanalai Nguyen Xuan Xa Joon Sup Yeom Lukas Hermawan Angela Devine Spike Nowak Indra Jaya Supargiyono Supargiyono Koen Peeters Grietens Ric N. Price |
spellingShingle |
Kamala Thriemer Albino Bobogare Benedikt Ley Clarice Samo Gudo Mohammad Shafiul Alam Nick M. Anstey Elizabeth Ashley J. Kevin Baird Charlotte Gryseels Elodie Jambert Marcus Lacerda Ferdinand Laihad Jutta Marfurt Ayodhia Pitaloka Pasaribu Jeanne Rini Poespoprodjo Inge Sutanto Walter R. Taylor Christel van den Boogaard Katherine E. Battle Lek Dysoley Prakash Ghimire Bill Hawley Jimee Hwang Wasif Ali Khan Rose Nani Binti Mudin Maria Endang Sumiwi Rukhsana Ahmed M. M. Aktaruzzaman Kiran Raj Awasthi Azucena Bardaji David Bell Leonard Boaz Faustina Helen Burdam Daniel Chandramohan Qin Cheng Keobouphaphone Chindawongsa Janice Culpepper Santasabuj Das Raffy Deray Meghna Desai Gonzalo Domingo Wang Duoquan Stephan Duparc Rustini Floranita Emily Gerth-Guyette Rosalind E. Howes Cecilia Hugo George Jagoe Elvieda Sariwati Sanya Tahmina Jhora Wu Jinwei Harin Karunajeewa Enny Kenangalem Bibek Kumar Lal Chandra Landuwulang Emmanuel Le Perru Sang-Eun Lee Leo Sora Makita James McCarthy Asrat Mekuria Neelima Mishra Esau Naket Simone Nambanya Johnny Nausien Thang Ngo Duc Thuan Nguyen Thi Rinitis Noviyanti Daniel Pfeffer Gao Qi Annisa Rahmalia Stephen Rogerson Iriani Samad Jetsumon Sattabongkot Ari Satyagraha Dennis Shanks Surender Nath Sharma Carol Hopkins Sibley Ali Sungkar Din Syafruddin Arunansu Talukdar Joel Tarning Feiko ter Kuile Suman Thapa Minerva Theodora Tho Tran Huy Edward Waramin Govert Waramori Adugna Woyessa Chansuda Wongsrichanalai Nguyen Xuan Xa Joon Sup Yeom Lukas Hermawan Angela Devine Spike Nowak Indra Jaya Supargiyono Supargiyono Koen Peeters Grietens Ric N. Price Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group Malaria Journal Vivax malaria Plasmodium vivax Adherence Effectiveness Efficacy Radical cure |
author_facet |
Kamala Thriemer Albino Bobogare Benedikt Ley Clarice Samo Gudo Mohammad Shafiul Alam Nick M. Anstey Elizabeth Ashley J. Kevin Baird Charlotte Gryseels Elodie Jambert Marcus Lacerda Ferdinand Laihad Jutta Marfurt Ayodhia Pitaloka Pasaribu Jeanne Rini Poespoprodjo Inge Sutanto Walter R. Taylor Christel van den Boogaard Katherine E. Battle Lek Dysoley Prakash Ghimire Bill Hawley Jimee Hwang Wasif Ali Khan Rose Nani Binti Mudin Maria Endang Sumiwi Rukhsana Ahmed M. M. Aktaruzzaman Kiran Raj Awasthi Azucena Bardaji David Bell Leonard Boaz Faustina Helen Burdam Daniel Chandramohan Qin Cheng Keobouphaphone Chindawongsa Janice Culpepper Santasabuj Das Raffy Deray Meghna Desai Gonzalo Domingo Wang Duoquan Stephan Duparc Rustini Floranita Emily Gerth-Guyette Rosalind E. Howes Cecilia Hugo George Jagoe Elvieda Sariwati Sanya Tahmina Jhora Wu Jinwei Harin Karunajeewa Enny Kenangalem Bibek Kumar Lal Chandra Landuwulang Emmanuel Le Perru Sang-Eun Lee Leo Sora Makita James McCarthy Asrat Mekuria Neelima Mishra Esau Naket Simone Nambanya Johnny Nausien Thang Ngo Duc Thuan Nguyen Thi Rinitis Noviyanti Daniel Pfeffer Gao Qi Annisa Rahmalia Stephen Rogerson Iriani Samad Jetsumon Sattabongkot Ari Satyagraha Dennis Shanks Surender Nath Sharma Carol Hopkins Sibley Ali Sungkar Din Syafruddin Arunansu Talukdar Joel Tarning Feiko ter Kuile Suman Thapa Minerva Theodora Tho Tran Huy Edward Waramin Govert Waramori Adugna Woyessa Chansuda Wongsrichanalai Nguyen Xuan Xa Joon Sup Yeom Lukas Hermawan Angela Devine Spike Nowak Indra Jaya Supargiyono Supargiyono Koen Peeters Grietens Ric N. Price |
author_sort |
Kamala Thriemer |
title |
Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group |
title_short |
Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group |
title_full |
Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group |
title_fullStr |
Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group |
title_full_unstemmed |
Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group |
title_sort |
quantifying primaquine effectiveness and improving adherence: a round table discussion of the apmen vivax working group |
publisher |
BMC |
series |
Malaria Journal |
issn |
1475-2875 |
publishDate |
2018-06-01 |
description |
Abstract The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported. Context specific strategies to improve adherence are needed to increase understanding and awareness of PQ within affected communities; these must include education and health promotion programs. Lessons learned from other disease programs highlight that a package of approaches has the greatest potential to change patient and prescriber habits, however optimizing the components of this approach and quantifying their effectiveness is challenging. In a trial setting, the reactivity of participants results in patients altering their behaviour and creates inherent bias. Although bias can be reduced by integrating data collection into the routine health care and surveillance systems, this comes at a cost of decreasing the detection of clinical outcomes. Measuring adherence and the factors that relate to it, also requires an in-depth understanding of the context and the underlying sociocultural logic that supports it. Reaching the elimination goal will require innovative approaches to improve radical cure for vivax malaria, as well as the methods to evaluate its effectiveness. |
topic |
Vivax malaria Plasmodium vivax Adherence Effectiveness Efficacy Radical cure |
url |
http://link.springer.com/article/10.1186/s12936-018-2380-8 |
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doaj-7100b6c9fcb54db685313d5d9589f4782020-11-24T22:15:14ZengBMCMalaria Journal1475-28752018-06-011711710.1186/s12936-018-2380-8Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working GroupKamala Thriemer0Albino Bobogare1Benedikt Ley2Clarice Samo Gudo3Mohammad Shafiul Alam4Nick M. Anstey5Elizabeth Ashley6J. Kevin Baird7Charlotte Gryseels8Elodie Jambert9Marcus Lacerda10Ferdinand Laihad11Jutta Marfurt12Ayodhia Pitaloka Pasaribu13Jeanne Rini Poespoprodjo14Inge Sutanto15Walter R. Taylor16Christel van den Boogaard17Katherine E. Battle18Lek Dysoley19Prakash Ghimire20Bill Hawley21Jimee Hwang22Wasif Ali Khan23Rose Nani Binti Mudin24Maria Endang Sumiwi25Rukhsana Ahmed26M. M. Aktaruzzaman27Kiran Raj Awasthi28Azucena Bardaji29David Bell30Leonard Boaz31Faustina Helen Burdam32Daniel Chandramohan33Qin Cheng34Keobouphaphone Chindawongsa35Janice Culpepper36Santasabuj Das37Raffy Deray38Meghna Desai39Gonzalo Domingo40Wang Duoquan41Stephan Duparc42Rustini Floranita43Emily Gerth-Guyette44Rosalind E. Howes45Cecilia Hugo46George Jagoe47Elvieda Sariwati48Sanya Tahmina Jhora49Wu Jinwei50Harin Karunajeewa51Enny Kenangalem52Bibek Kumar Lal53Chandra Landuwulang54Emmanuel Le Perru55Sang-Eun Lee56Leo Sora Makita57James McCarthy58Asrat Mekuria59Neelima Mishra60Esau Naket61Simone Nambanya62Johnny Nausien63Thang Ngo Duc64Thuan Nguyen Thi65Rinitis Noviyanti66Daniel Pfeffer67Gao Qi68Annisa Rahmalia69Stephen Rogerson70Iriani Samad71Jetsumon Sattabongkot72Ari Satyagraha73Dennis Shanks74Surender Nath Sharma75Carol Hopkins Sibley76Ali Sungkar77Din Syafruddin78Arunansu Talukdar79Joel Tarning80Feiko ter Kuile81Suman Thapa82Minerva Theodora83Tho Tran Huy84Edward Waramin85Govert Waramori86Adugna Woyessa87Chansuda Wongsrichanalai88Nguyen Xuan Xa89Joon Sup Yeom90Lukas Hermawan91Angela Devine92Spike Nowak93Indra Jaya94Supargiyono Supargiyono95Koen Peeters Grietens96Ric N. Price97Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, DarwinMinistry of Health and Medical Services, National Vector-Borne Disease Control ProgrammeGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, DarwinIndependent ConsultantInternational Center for Diarrheal Diseases (ICDDR,B)Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, DarwinMyanmar-Oxford Clinical Research UnitCentre for Tropical Medicine and Global Health, University of OxfordInstitute of Tropical Medicine AntwerpMedicines for Malaria Venture (MMV)Instituto Leônidas & Maria Deane (Fiocruz)National Forum on Indonesia RBM/National Forum on Gebrak MalariaGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, DarwinUniversitas Sumatera UtaraYayasan Pengembangan Kesehatan dan Masyarakat, Papua (YPKMP)University of IndonesiaCentre for Tropical Medicine and Global Health, University of OxfordGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, DarwinMalaria Atlas Project (MAP), Big Data Institute, University of OxfordNational Center for Parasitology, Entomology and Malaria ControlMicrobiology Department, Tribhuvan UniversityEntomology Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and PreventionPresident’s Malaria Initiative, Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and PreventionInternational Center for Diarrheal Diseases (ICDDR,B)Disease Control Division, Ministry of HealthUNICEF IndonesiaLiverpool School of Tropical MedicineDirectorate General of Health Services, Ministry of Health & Family Welfare Government of the People’s Republic of BangladeshSave The ChildrenISGlobal, Hospital Clínic-Universitat de BarcelonaIntellectual Ventures Global Good FundMinistry of Health and Medical Services, National Vector-Borne Disease Control ProgrammeYayasan Pengembangan Kesehatan dan Masyarakat, Papua (YPKMP)The London School of Hygiene & Tropical Medicine (LSHTM)Australian Defence Force Malaria and Infectious Disease InstituteCenter of Malariology, Parasitology and Entomology, Communicable Diseases ControlBill & Melinda Gates FoundationIndian Council of Medical ResearchDepartment of Health, National Centre for Disease Control & PreventionMalaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and PreventionPATHNational Institute of Parasitic Diseases, China CDCMedicines for Malaria Venture (MMV)WHO OfficePATHMalaria Atlas Project (MAP), Big Data Institute, University of OxfordACTMalariaMedicines for Malaria Venture (MMV)Ministry of Health, National Malaria Control ProgramDirectorate General of Health Services, Ministry of Health & Family Welfare Government of the People’s Republic of BangladeshTengchong Center for Disease Control and PreventionWalter and Eliza Hall Institute of Medical ResearchYayasan Pengembangan Kesehatan dan Masyarakat, Papua (YPKMP)Epidemiology & Disease Control Division, Department of Health Services, Ministry of Health and PopulationPapuan Health and Community Development FoundationMinistry of HealthDivision of Vectors and Parasitic Diseases, Korea Centers for Disease Control and PreventionMinistry of Health, National Malaria Control ProgrammeQIMR Berghofer Medical Research InstituteSchool of Medicine, Addis Ababa UniversityIndian Council of Medical ResearchMinistry of Health, Malaria and Other Vector-Borne Diseases Control Program (MOVBDCP)Center of Malariology, Parasitology and Entomology, Communicable Diseases ControlMinistry of Health, Malaria and Other Vector-Borne Diseases Control Program (MOVBDCP)National Institute of Malariology, Parasitology and Entomology (NIMPE)National Institute of Malariology, Parasitology and Entomology (NIMPE)Eijkman Institute for Molecular BiologyGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, DarwinJiangsu Institute of Parasitic DiseasesTuberculosis-HIV Research Center Faculty of Medicine, Universitas PadjadjaranDepartment of Medicine at the Doherty Institute, University of MelbourneMinistry of Health, National Malaria Control ProgramMahidol Vivax Research Unit, Faculty of Tropical MedicineEijkman Institute for Molecular BiologyAustralian Defence Force Malaria and Infectious Disease InstituteNational Vector Borne Disease Control Programme Directorate General of Health Services Ministry of Health & Family WelfareWorldWide Antimalarial Resistance Network (WWARN)Family Health Directorate, Ministry of HealthEijkman Institute for Molecular BiologyMedicine Department, Medical College KolkataMahidol Oxford Clinical Research Unit (MORU)Liverpool School of Tropical MedicineSave The ChildrenMinistry of Health, National Malaria Control ProgramNational Institute of Malariology, Parasitology and Entomology (NIMPE)Family Health Services, Ministry of HealthFreeport IndonesiaEthiopian Public Health Institute (EPHI)Independent ConsultantNational Institute of Malariology, Parasitology and Entomology (NIMPE)Yonsei University College of MedicineFamily Health Directorate, Ministry of HealthGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, DarwinPATHProgram and Information Department, Directorate General of Disease Prevention and ControlUniversity of Gadjah MadaInstitute of Tropical Medicine AntwerpGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, DarwinAbstract The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and the methodological difficulties in assessing clinical effectiveness of radical cure. The salient discussions of this meeting which involved 110 representatives from 18 partner countries and 21 institutional partner organizations are reported. Context specific strategies to improve adherence are needed to increase understanding and awareness of PQ within affected communities; these must include education and health promotion programs. Lessons learned from other disease programs highlight that a package of approaches has the greatest potential to change patient and prescriber habits, however optimizing the components of this approach and quantifying their effectiveness is challenging. In a trial setting, the reactivity of participants results in patients altering their behaviour and creates inherent bias. Although bias can be reduced by integrating data collection into the routine health care and surveillance systems, this comes at a cost of decreasing the detection of clinical outcomes. Measuring adherence and the factors that relate to it, also requires an in-depth understanding of the context and the underlying sociocultural logic that supports it. Reaching the elimination goal will require innovative approaches to improve radical cure for vivax malaria, as well as the methods to evaluate its effectiveness.http://link.springer.com/article/10.1186/s12936-018-2380-8Vivax malariaPlasmodium vivaxAdherenceEffectivenessEfficacyRadical cure |