Neonatal Brain Abscess due to Extended-Spectrum Beta-Lactamase Producing Klebsiella pneumoniae

• Main Authors: Biswajit Biswas, Monojit Mondal, Rajoo Thapa, Debkrishna Mallick, Asok Kumar Datta
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2014-11-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: brain abscess; esbl; klebsiella sepsis
• Online Access: https://jcdr.net/articles/PDF/5198/10160_CE(NJ)_F(Sh)_PF1(NJAK)_PFA(Sh)_PF2(PAG).pdf

Klebsiella pneumoniae (K. pneumoniae) causing brain abscess in newborn infants is rare. Presented herein, is a 27-day-old male neonate who developed two frontal lobe abscesses in association with K. pneumoniae sepsis and meningitis. Antibiotic susceptibility testing utilizing the double-disk synergy method (Cefotaxime and Amoxycillin-Clavulanate) confirmed the extended spectrum betalactamase (ESBL) production by the isolate. He was treated simultaneously with antibiotics (Meropenem and Amikacin) and abscess aspiration through the anterior fontanelle, with less than satisfactory outcome. ESBL producing K. pneumoniae brain abscess in neonates is extremely rare in the English literature. Emperical carbapenems and aminoglycoside coverage in neonates with K. pneumoniae sepsis and brain abscess, especially in areas with high rate of ESBL producing bacteria may be warranted.