Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3

Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3

Experimental autoimmune encephalomyelitis (EAE) involves inflammatory cell infiltration into the central nervous system (CNS) and models the human disease multiple sclerosis. Here the authors show that transferred CD4+ gut intraepithelial lymphocytes can migrate into the CNS and inhibit inflammation...

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Main Authors: Atsushi Kadowaki, Sachiko Miyake, Ryoko Saga, Asako Chiba, Hideki Mochizuki, Takashi Yamamura
Format: Article
Language:English
Published: Nature Publishing Group 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11639
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spelling doaj-71209c17bb16432bb7ba84d38a0646fd2021-05-11T11:17:32ZengNature Publishing GroupNature Communications2041-17232016-05-017111610.1038/ncomms11639Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3Atsushi Kadowaki0Sachiko Miyake1Ryoko Saga2Asako Chiba3Hideki Mochizuki4Takashi Yamamura5Department of Immunology, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Neurology, Osaka University Graduate School of MedicineDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and PsychiatryExperimental autoimmune encephalomyelitis (EAE) involves inflammatory cell infiltration into the central nervous system (CNS) and models the human disease multiple sclerosis. Here the authors show that transferred CD4+ gut intraepithelial lymphocytes can migrate into the CNS and inhibit inflammation in recipient mice with EAE.https://doi.org/10.1038/ncomms11639
collection DOAJ
language English
format Article
sources DOAJ
author Atsushi Kadowaki
Sachiko Miyake
Ryoko Saga
Asako Chiba
Hideki Mochizuki
Takashi Yamamura
spellingShingle Atsushi Kadowaki
Sachiko Miyake
Ryoko Saga
Asako Chiba
Hideki Mochizuki
Takashi Yamamura
Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
Nature Communications
author_facet Atsushi Kadowaki
Sachiko Miyake
Ryoko Saga
Asako Chiba
Hideki Mochizuki
Takashi Yamamura
author_sort Atsushi Kadowaki
title Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
title_short Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
title_full Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
title_fullStr Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
title_full_unstemmed Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
title_sort gut environment-induced intraepithelial autoreactive cd4+ t cells suppress central nervous system autoimmunity via lag-3
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-05-01
description Experimental autoimmune encephalomyelitis (EAE) involves inflammatory cell infiltration into the central nervous system (CNS) and models the human disease multiple sclerosis. Here the authors show that transferred CD4+ gut intraepithelial lymphocytes can migrate into the CNS and inhibit inflammation in recipient mice with EAE.
url https://doi.org/10.1038/ncomms11639
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