Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
Experimental autoimmune encephalomyelitis (EAE) involves inflammatory cell infiltration into the central nervous system (CNS) and models the human disease multiple sclerosis. Here the authors show that transferred CD4+ gut intraepithelial lymphocytes can migrate into the CNS and inhibit inflammation...
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2016-05-01
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Online Access: | https://doi.org/10.1038/ncomms11639 |
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doaj-71209c17bb16432bb7ba84d38a0646fd2021-05-11T11:17:32ZengNature Publishing GroupNature Communications2041-17232016-05-017111610.1038/ncomms11639Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3Atsushi Kadowaki0Sachiko Miyake1Ryoko Saga2Asako Chiba3Hideki Mochizuki4Takashi Yamamura5Department of Immunology, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and PsychiatryDepartment of Neurology, Osaka University Graduate School of MedicineDepartment of Immunology, National Institute of Neuroscience, National Center of Neurology and PsychiatryExperimental autoimmune encephalomyelitis (EAE) involves inflammatory cell infiltration into the central nervous system (CNS) and models the human disease multiple sclerosis. Here the authors show that transferred CD4+ gut intraepithelial lymphocytes can migrate into the CNS and inhibit inflammation in recipient mice with EAE.https://doi.org/10.1038/ncomms11639 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Atsushi Kadowaki Sachiko Miyake Ryoko Saga Asako Chiba Hideki Mochizuki Takashi Yamamura |
spellingShingle |
Atsushi Kadowaki Sachiko Miyake Ryoko Saga Asako Chiba Hideki Mochizuki Takashi Yamamura Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3 Nature Communications |
author_facet |
Atsushi Kadowaki Sachiko Miyake Ryoko Saga Asako Chiba Hideki Mochizuki Takashi Yamamura |
author_sort |
Atsushi Kadowaki |
title |
Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3 |
title_short |
Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3 |
title_full |
Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3 |
title_fullStr |
Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3 |
title_full_unstemmed |
Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3 |
title_sort |
gut environment-induced intraepithelial autoreactive cd4+ t cells suppress central nervous system autoimmunity via lag-3 |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-05-01 |
description |
Experimental autoimmune encephalomyelitis (EAE) involves inflammatory cell infiltration into the central nervous system (CNS) and models the human disease multiple sclerosis. Here the authors show that transferred CD4+ gut intraepithelial lymphocytes can migrate into the CNS and inhibit inflammation in recipient mice with EAE. |
url |
https://doi.org/10.1038/ncomms11639 |
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