Association of Parity in Patients with Chronic Liver Disease

Introduction and aim. The impact of type of liver disease on parity rates hasn’t been described. Our aim was to assess the parity rates among women with CLD.Material and methods. The National Health and Nutrition Examination Survey-III (19881994) data were used to identify adult female participants...

Full description

Bibliographic Details
Main Authors: Pegah Golabi, Sofie Fazel, Munkhzul Otgonsuren, Carey Escheik, Mehmet Sayiner, Zobair M. Younossi
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Annals of Hepatology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S166526811931066X
id doaj-7124edb7ca9346889a213e22ab7387a1
record_format Article
spelling doaj-7124edb7ca9346889a213e22ab7387a12021-06-09T05:53:19ZengElsevierAnnals of Hepatology1665-26812018-11-0117610351041Association of Parity in Patients with Chronic Liver DiseasePegah Golabi0Sofie Fazel1Munkhzul Otgonsuren2Carey Escheik3Mehmet Sayiner4Zobair M. Younossi5Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United StatesBetty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United StatesBetty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United StatesBetty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United StatesBetty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United States; Center For Liver Disease, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA, United StatesBetty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United States; Center For Liver Disease, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA, United States; Correspondence and reprint request:Introduction and aim. The impact of type of liver disease on parity rates hasn’t been described. Our aim was to assess the parity rates among women with CLD.Material and methods. The National Health and Nutrition Examination Survey-III (19881994) data were used to identify adult female participants with a diagnosis of CLD. Participants were asked about their reproductive health status. Parity was defined as having at least one live birth. Hepatic ultrasound, serologic, medical examination and clinical data were available to determine the presence and type of CLD. Body mass index (kg/m2) was divided into 3 categories (< 30; 3035; 36+).Results. A total of 3,502 (865 NAFLD, 737 other CLD, 1,901 control) subjects were included. Patients with NAFLD were more likely to have at least one live birth than patients with other CLD and controls (77% in NAFLD vs. 72% in controls). Multivariate analysis revealed that presence of CLD other than NAFLD (OR: 0.46 [95% CI, 0.34-0.63]) and having a college or higher degree (OR: 0.48 [95% CI, 0.34-0.68]) were negatively associated while having low income (OR: 11.06 [95% CI, 6.86-17.82]) and being African American (OR: 3.93 [95% CI, 2.59-5.98]) were positively associated with having at least one live birth.Conclusions. This study revealed that patients with CLD other than NAFLD were less likely to have at least one live birth. NAFLD and obesity were associated with higher rates of live births which can potentially be explained by weight gain post live birth leading to obesity and its associated-NAFLD.http://www.sciencedirect.com/science/article/pii/S166526811931066XNon-alcoholic fatty liver diseasePregnancyInfertilityPolycystic ovary syndromeInsulin resistance
collection DOAJ
language English
format Article
sources DOAJ
author Pegah Golabi
Sofie Fazel
Munkhzul Otgonsuren
Carey Escheik
Mehmet Sayiner
Zobair M. Younossi
spellingShingle Pegah Golabi
Sofie Fazel
Munkhzul Otgonsuren
Carey Escheik
Mehmet Sayiner
Zobair M. Younossi
Association of Parity in Patients with Chronic Liver Disease
Annals of Hepatology
Non-alcoholic fatty liver disease
Pregnancy
Infertility
Polycystic ovary syndrome
Insulin resistance
author_facet Pegah Golabi
Sofie Fazel
Munkhzul Otgonsuren
Carey Escheik
Mehmet Sayiner
Zobair M. Younossi
author_sort Pegah Golabi
title Association of Parity in Patients with Chronic Liver Disease
title_short Association of Parity in Patients with Chronic Liver Disease
title_full Association of Parity in Patients with Chronic Liver Disease
title_fullStr Association of Parity in Patients with Chronic Liver Disease
title_full_unstemmed Association of Parity in Patients with Chronic Liver Disease
title_sort association of parity in patients with chronic liver disease
publisher Elsevier
series Annals of Hepatology
issn 1665-2681
publishDate 2018-11-01
description Introduction and aim. The impact of type of liver disease on parity rates hasn’t been described. Our aim was to assess the parity rates among women with CLD.Material and methods. The National Health and Nutrition Examination Survey-III (19881994) data were used to identify adult female participants with a diagnosis of CLD. Participants were asked about their reproductive health status. Parity was defined as having at least one live birth. Hepatic ultrasound, serologic, medical examination and clinical data were available to determine the presence and type of CLD. Body mass index (kg/m2) was divided into 3 categories (< 30; 3035; 36+).Results. A total of 3,502 (865 NAFLD, 737 other CLD, 1,901 control) subjects were included. Patients with NAFLD were more likely to have at least one live birth than patients with other CLD and controls (77% in NAFLD vs. 72% in controls). Multivariate analysis revealed that presence of CLD other than NAFLD (OR: 0.46 [95% CI, 0.34-0.63]) and having a college or higher degree (OR: 0.48 [95% CI, 0.34-0.68]) were negatively associated while having low income (OR: 11.06 [95% CI, 6.86-17.82]) and being African American (OR: 3.93 [95% CI, 2.59-5.98]) were positively associated with having at least one live birth.Conclusions. This study revealed that patients with CLD other than NAFLD were less likely to have at least one live birth. NAFLD and obesity were associated with higher rates of live births which can potentially be explained by weight gain post live birth leading to obesity and its associated-NAFLD.
topic Non-alcoholic fatty liver disease
Pregnancy
Infertility
Polycystic ovary syndrome
Insulin resistance
url http://www.sciencedirect.com/science/article/pii/S166526811931066X
work_keys_str_mv AT pegahgolabi associationofparityinpatientswithchronicliverdisease
AT sofiefazel associationofparityinpatientswithchronicliverdisease
AT munkhzulotgonsuren associationofparityinpatientswithchronicliverdisease
AT careyescheik associationofparityinpatientswithchronicliverdisease
AT mehmetsayiner associationofparityinpatientswithchronicliverdisease
AT zobairmyounossi associationofparityinpatientswithchronicliverdisease
_version_ 1721388832655409152