Biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control study
Introduction : On average, 19–23% of patients with acute myocardial infarction (MI) suffer from type 2 diabetes mellitus, which is newly diagnosed in a significant number of patients. Both classic carbohydrate metabolism and lipid metabolism may be promising diagnostic markers for insulin resistance...
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doaj-712783830055424bb6da741c8065595d2020-11-25T00:33:02ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512017-01-0113231132010.5114/aoms.2017.6524029146Biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control studyOlga BarbarashOlga GruzdevaEvgenya UchasovaEkaterina BelikYulia DylevaVictoria KaretnikovaIntroduction : On average, 19–23% of patients with acute myocardial infarction (MI) suffer from type 2 diabetes mellitus, which is newly diagnosed in a significant number of patients. Both classic carbohydrate metabolism and lipid metabolism may be promising diagnostic markers for insulin resistance in acute coronary syndrome. Material and methods : Two hundred patients (130 males and 70 females aged 61.4 ±1.12 years) with ST-segment elevation MI were included in the study. Patients were divided into two groups based on manifestations of diabetes: (1) 171 patients without diabetes within 1 year after MI; and (2) 29 patients with manifestations of diabetes. The control group comprised 33 people without diseases of the cardiovascular system and diabetes and was matched by age and gender with patients. Results : In patients with an imbalanced adipokine state during the acute phase of MI, we noted an increased concentration of free fatty acids (p > 0.05) and reduced ghrelin levels and activation of the proinflammatory and thrombotic potentials of blood plasma. Patients who developed diabetes 1 year after MI showed hospital stays with more pronounced changes in the study parameters. Conclusions : The most informative biochemical parameters associated with the development of diabetes at 1 year after MI were adiponectin, retinol protein, ghrelin, tumor necrosis factor , and plasminogen activator inhibitor.https://www.termedia.pl/Biochemical-markers-of-type-2-diabetes-as-a-late-complication-of-myocardial-infarction-a-case-control-study,19,29146,1,1.htmltype 2 diabetes mellitus adipokines ghrelin tumor necrosis factor myocardial infarction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Olga Barbarash Olga Gruzdeva Evgenya Uchasova Ekaterina Belik Yulia Dyleva Victoria Karetnikova |
spellingShingle |
Olga Barbarash Olga Gruzdeva Evgenya Uchasova Ekaterina Belik Yulia Dyleva Victoria Karetnikova Biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control study Archives of Medical Science type 2 diabetes mellitus adipokines ghrelin tumor necrosis factor myocardial infarction |
author_facet |
Olga Barbarash Olga Gruzdeva Evgenya Uchasova Ekaterina Belik Yulia Dyleva Victoria Karetnikova |
author_sort |
Olga Barbarash |
title |
Biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control study |
title_short |
Biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control study |
title_full |
Biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control study |
title_fullStr |
Biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control study |
title_full_unstemmed |
Biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control study |
title_sort |
biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control study |
publisher |
Termedia Publishing House |
series |
Archives of Medical Science |
issn |
1734-1922 1896-9151 |
publishDate |
2017-01-01 |
description |
Introduction : On average, 19–23% of patients with acute myocardial infarction (MI) suffer from type 2 diabetes mellitus, which is newly diagnosed in a significant number of patients. Both classic carbohydrate metabolism and lipid metabolism may be promising diagnostic markers for insulin resistance in acute coronary syndrome.
Material and methods : Two hundred patients (130 males and 70 females aged 61.4 ±1.12 years) with ST-segment elevation MI were included in the study. Patients were divided into two groups based on manifestations of diabetes: (1) 171 patients without diabetes within 1 year after MI; and (2) 29 patients with manifestations of diabetes. The control group comprised 33 people without diseases of the cardiovascular system and diabetes and was matched by age and gender with patients.
Results : In patients with an imbalanced adipokine state during the acute phase of MI, we noted an increased concentration of free fatty acids (p > 0.05) and reduced ghrelin levels and activation of the proinflammatory and thrombotic potentials of blood plasma. Patients who developed diabetes 1 year after MI showed hospital stays with more pronounced changes in the study parameters.
Conclusions : The most informative biochemical parameters associated with the development of diabetes at 1 year after MI were adiponectin, retinol protein, ghrelin, tumor necrosis factor , and plasminogen activator inhibitor. |
topic |
type 2 diabetes mellitus adipokines ghrelin tumor necrosis factor myocardial infarction |
url |
https://www.termedia.pl/Biochemical-markers-of-type-2-diabetes-as-a-late-complication-of-myocardial-infarction-a-case-control-study,19,29146,1,1.html |
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