Misdiagnosis of Myasthenia Gravis and Subsequent Clinical Implication; A case report and review of literature

The autoimmune disease, myasthenia gravis (MG), can mimic a variety of neurological disorders leading to a delay in diagnosis and treatment. On occasions, misdiagnosis of MG could lead to unnecessary and potentially harmful therapeutic interventions. We report on a 12 year-old boy, in whom MG was mi...

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Main Authors: Abdullah Al-Asmi, Ramachandiran Nandhagopal, P C Jacob, Arunodaya Gujjar
Format: Article
Language:English
Published: Sultan Qaboos University 2012-02-01
Series:Sultan Qaboos University Medical Journal
Subjects:
Online Access:http://web.squ.edu.om/squmj/includes/tng/pub/tNG_download.asp?id=157562d5f358efebf08be3ab9e8c76d2
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spelling doaj-712aba9a6401418589ff2db266bdac552020-11-24T20:51:58ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal 2075-051X2075-05282012-02-01121103108Misdiagnosis of Myasthenia Gravis and Subsequent Clinical Implication; A case report and review of literatureAbdullah Al-Asmi0Ramachandiran Nandhagopal1P C Jacob2Arunodaya Gujjar3Department of Medicine, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Medicine, Sultan Qaboos University Hospital, Muscat, OmanDepartment of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, OmanDepartment of Medicine, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, OmanThe autoimmune disease, myasthenia gravis (MG), can mimic a variety of neurological disorders leading to a delay in diagnosis and treatment. On occasions, misdiagnosis of MG could lead to unnecessary and potentially harmful therapeutic interventions. We report on a 12 year-old boy, in whom MG was mistaken for meningitic sequelae and subsequently for critical neuropathy/myopathy resulting in considerable morbidity for nearly a decade. Subsequent correct diagnosis and optimal management resulted in significant improvement in his functional status. We discuss the importance of considering MG as one of the potential differential diagnoses among cases of recurrent respiratory pump failure, or unexplained bulbar symptoms where documentary proof of the previous diagnoses including work-up for MG is lacking. We also review the literature on MG misdiagnosis and highlight the potential pitfalls in MG diagnosis.http://web.squ.edu.om/squmj/includes/tng/pub/tNG_download.asp?id=157562d5f358efebf08be3ab9e8c76d2Myasthenia gravisBulbar palsyPneumoniaMeningitis sequelaeCase reportOman
collection DOAJ
language English
format Article
sources DOAJ
author Abdullah Al-Asmi
Ramachandiran Nandhagopal
P C Jacob
Arunodaya Gujjar
spellingShingle Abdullah Al-Asmi
Ramachandiran Nandhagopal
P C Jacob
Arunodaya Gujjar
Misdiagnosis of Myasthenia Gravis and Subsequent Clinical Implication; A case report and review of literature
Sultan Qaboos University Medical Journal
Myasthenia gravis
Bulbar palsy
Pneumonia
Meningitis sequelae
Case report
Oman
author_facet Abdullah Al-Asmi
Ramachandiran Nandhagopal
P C Jacob
Arunodaya Gujjar
author_sort Abdullah Al-Asmi
title Misdiagnosis of Myasthenia Gravis and Subsequent Clinical Implication; A case report and review of literature
title_short Misdiagnosis of Myasthenia Gravis and Subsequent Clinical Implication; A case report and review of literature
title_full Misdiagnosis of Myasthenia Gravis and Subsequent Clinical Implication; A case report and review of literature
title_fullStr Misdiagnosis of Myasthenia Gravis and Subsequent Clinical Implication; A case report and review of literature
title_full_unstemmed Misdiagnosis of Myasthenia Gravis and Subsequent Clinical Implication; A case report and review of literature
title_sort misdiagnosis of myasthenia gravis and subsequent clinical implication; a case report and review of literature
publisher Sultan Qaboos University
series Sultan Qaboos University Medical Journal
issn 2075-051X
2075-0528
publishDate 2012-02-01
description The autoimmune disease, myasthenia gravis (MG), can mimic a variety of neurological disorders leading to a delay in diagnosis and treatment. On occasions, misdiagnosis of MG could lead to unnecessary and potentially harmful therapeutic interventions. We report on a 12 year-old boy, in whom MG was mistaken for meningitic sequelae and subsequently for critical neuropathy/myopathy resulting in considerable morbidity for nearly a decade. Subsequent correct diagnosis and optimal management resulted in significant improvement in his functional status. We discuss the importance of considering MG as one of the potential differential diagnoses among cases of recurrent respiratory pump failure, or unexplained bulbar symptoms where documentary proof of the previous diagnoses including work-up for MG is lacking. We also review the literature on MG misdiagnosis and highlight the potential pitfalls in MG diagnosis.
topic Myasthenia gravis
Bulbar palsy
Pneumonia
Meningitis sequelae
Case report
Oman
url http://web.squ.edu.om/squmj/includes/tng/pub/tNG_download.asp?id=157562d5f358efebf08be3ab9e8c76d2
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AT pcjacob misdiagnosisofmyastheniagravisandsubsequentclinicalimplicationacasereportandreviewofliterature
AT arunodayagujjar misdiagnosisofmyastheniagravisandsubsequentclinicalimplicationacasereportandreviewofliterature
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