SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the high fatality rate of coronavirus disease 2019 (COVID-19) have been putting a strain on the world since December 2019. Infected individuals exhibit unpredictable symptoms that tend to worsen if age is advanced,...
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doaj-712bcb2116ce4d8ca4d78b04edf3d38c2020-11-25T03:56:59ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-11-011110.3389/fphys.2020.571367571367SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19Matteo Briguglio0Mauro Porta1Francesca Zuffada2Alberto R. Bona3Tiziano Crespi4Fabio Pino5Paolo Perazzo6Marco Mazzocchi7Riccardo Giorgino8Giuseppe De Angelis9Alfonso Ielasi10Giuseppe De Blasio11Maurizio Turiel12IRCCS Orthopedic Institute Galeazzi, Scientific Direction, Milan, ItalyIRCCS Orthopedic Institute Galeazzi, Neurology Unit, Milan, ItalyICCS Istituto Clinico Città Studi, Cardiology Unit, Milan, ItalyICCS Istituto Clinico Città Studi, Neurosurgery Unit, Milan, ItalyIRCCS Orthopedic Institute Galeazzi, Intensive Care Unit, Milan, ItalyIRCCS Orthopedic Institute Galeazzi, Intensive Care Unit, Milan, ItalyIRCCS Orthopedic Institute Galeazzi, Intensive Care Unit, Milan, ItalyIRCCS Orthopedic Institute Galeazzi, Intensive Care Unit, Milan, ItalyUniversity of Milan, Residency Program in Orthopedics and Traumatology, Milan, ItalyASST Rhodense, Cardiology Unit, Rho, ItalyIstituto Clinico Sant’Ambrogio, Cardiology Unit, Milan, ItalyIRCCS Orthopedic Institute Galeazzi, Cardiology Unit, Milan, ItalyIRCCS Orthopedic Institute Galeazzi, Cardiology Unit, Milan, ItalyThe rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the high fatality rate of coronavirus disease 2019 (COVID-19) have been putting a strain on the world since December 2019. Infected individuals exhibit unpredictable symptoms that tend to worsen if age is advanced, a state of malnutrition persists, or if cardiovascular comorbidities are present. Once transmitted, the virus affects the lungs and in predisposed individuals can elicit a sequela of fatal cardiovascular consequences. We aim to present the pathophysiology of COVID-19, emphasizing the major cellular and clinical manifestations from a cardiological perspective. As a roaming viral particle or more likely via the Trojan horse route, SARS-CoV-2 can access different parts of the body. Cardiovascular features of COVID-19 can count myocardial injuries, vasculitis-like syndromes, and atherothrombotic manifestations. Deviations in the normal electrocardiogram pattern could hide pericardial effusion or cardiac inflammation, and dispersed microthrombi can cause ischemic damages, stroke, or even medullary reflex dysfunctions. Tailored treatment for reduced ejection fraction, arrhythmias, coronary syndromes, macrothrombosis and microthrombosis, and autonomic dysfunctions is mandatory. Confidently, evidence-based therapies for this multifaceted nevertheless purely cardiological COVID-19 will emerge after the global assessment of different approaches.https://www.frontiersin.org/articles/10.3389/fphys.2020.571367/fullcardiovascular systemcoronavirusSARS-CoV-2COVID-19infectionsvirulence |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matteo Briguglio Mauro Porta Francesca Zuffada Alberto R. Bona Tiziano Crespi Fabio Pino Paolo Perazzo Marco Mazzocchi Riccardo Giorgino Giuseppe De Angelis Alfonso Ielasi Giuseppe De Blasio Maurizio Turiel |
spellingShingle |
Matteo Briguglio Mauro Porta Francesca Zuffada Alberto R. Bona Tiziano Crespi Fabio Pino Paolo Perazzo Marco Mazzocchi Riccardo Giorgino Giuseppe De Angelis Alfonso Ielasi Giuseppe De Blasio Maurizio Turiel SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19 Frontiers in Physiology cardiovascular system coronavirus SARS-CoV-2 COVID-19 infections virulence |
author_facet |
Matteo Briguglio Mauro Porta Francesca Zuffada Alberto R. Bona Tiziano Crespi Fabio Pino Paolo Perazzo Marco Mazzocchi Riccardo Giorgino Giuseppe De Angelis Alfonso Ielasi Giuseppe De Blasio Maurizio Turiel |
author_sort |
Matteo Briguglio |
title |
SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19 |
title_short |
SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19 |
title_full |
SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19 |
title_fullStr |
SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19 |
title_full_unstemmed |
SARS-CoV-2 Aiming for the Heart: A Multicenter Italian Perspective About Cardiovascular Issues in COVID-19 |
title_sort |
sars-cov-2 aiming for the heart: a multicenter italian perspective about cardiovascular issues in covid-19 |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2020-11-01 |
description |
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the high fatality rate of coronavirus disease 2019 (COVID-19) have been putting a strain on the world since December 2019. Infected individuals exhibit unpredictable symptoms that tend to worsen if age is advanced, a state of malnutrition persists, or if cardiovascular comorbidities are present. Once transmitted, the virus affects the lungs and in predisposed individuals can elicit a sequela of fatal cardiovascular consequences. We aim to present the pathophysiology of COVID-19, emphasizing the major cellular and clinical manifestations from a cardiological perspective. As a roaming viral particle or more likely via the Trojan horse route, SARS-CoV-2 can access different parts of the body. Cardiovascular features of COVID-19 can count myocardial injuries, vasculitis-like syndromes, and atherothrombotic manifestations. Deviations in the normal electrocardiogram pattern could hide pericardial effusion or cardiac inflammation, and dispersed microthrombi can cause ischemic damages, stroke, or even medullary reflex dysfunctions. Tailored treatment for reduced ejection fraction, arrhythmias, coronary syndromes, macrothrombosis and microthrombosis, and autonomic dysfunctions is mandatory. Confidently, evidence-based therapies for this multifaceted nevertheless purely cardiological COVID-19 will emerge after the global assessment of different approaches. |
topic |
cardiovascular system coronavirus SARS-CoV-2 COVID-19 infections virulence |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2020.571367/full |
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