Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition

Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) patients suffer poor outcomes, including a five-year survival of below 10%. Poor outcomes result in part from therapeutic resistance that limits the impact of cytotoxic first-line therapy. Novel therapeutic approaches are needed, but curren...

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Bibliographic Details
Main Authors: Ryne C. Ramaker, Andrew A. Hardigan, Emily R. Gordon, Carter A. Wright, Richard M. Myers, Sara J. Cooper
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Cancer
Subjects:
Genome-wide screen
CRISPR
Pancreatic cancer
Drug resistance
ABCG2
HDAC1
Online Access:https://doi.org/10.1186/s12885-021-08388-1

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