Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia
Background/Aims: The aim of the following study is to compare the behavioral and psychological symptoms of dementia (BPSD) in patients of Alzheimer disease (AD) and vascular dementia (VaD). Materials and Methods: We used National Institute of Neurological and Communicative Disorders and Stroke-Alzhe...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2014-01-01
|
Series: | Annals of Indian Academy of Neurology |
Subjects: | |
Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=3;spage=325;epage=330;aulast=Bandyopadhyay |
id |
doaj-7138750baea04cc7ad717f08bb3b989c |
---|---|
record_format |
Article |
spelling |
doaj-7138750baea04cc7ad717f08bb3b989c2020-11-24T23:22:22ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492014-01-0117332533010.4103/0972-2327.138520Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementiaTushar Kanti BandyopadhyayAtanu BiswasArijit RoyDeb Sankar GuinGoutam GangopadhyaySujit SarkhelMalay Kumar GhoshalAsit Kumar SenapatiBackground/Aims: The aim of the following study is to compare the behavioral and psychological symptoms of dementia (BPSD) in patients of Alzheimer disease (AD) and vascular dementia (VaD). Materials and Methods: We used National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer′s Disease and Related Disorders Association criteria for diagnosing AD and National Institute of Neurological Disorders and Stroke-Association International pour la Recherche et l′Enseignement en Neurosciences Criteria for diagnosing VaD. VaD cohort was further subcategorized into small vessel and large vessel disease. The severity of cognitive impairment and the BPSD were studied by means of the Clinical Dementia Rating Scale (CDR) and the Neuropsychiatric Inventory respectively. Results: We studied 50 AD and 50 VaD patients of whom 38 were small vessels and 12 were large vessels VaD. The severity of dementia was comparable in both groups. The agitation/aggression, depression/dysphoria, anxiety, apathy/indifference, irritability, aberrant motor behavior, appetite and eating behavior and night-time behaviors occurred significantly more frequently in patients with VaD than AD. We found a weak positive correlation between the CDR score and the number of neuropsychiatric symptoms per patient in both cohorts. Elation/euphoria, agitation/aggression was significantly more frequent in patients with large vessel in comparison to small vessel VaD. Conclusions: BPSD are common in both types of dementia and they are more severe in VaD than AD when the groups have similar levels of cognitive impairment.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=3;spage=325;epage=330;aulast=BandyopadhyayAlzheimer diseasebehavioral and psychological symptoms of dementianeuropsychiatric inventorysmall vessel diseasevascular dementia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tushar Kanti Bandyopadhyay Atanu Biswas Arijit Roy Deb Sankar Guin Goutam Gangopadhyay Sujit Sarkhel Malay Kumar Ghoshal Asit Kumar Senapati |
spellingShingle |
Tushar Kanti Bandyopadhyay Atanu Biswas Arijit Roy Deb Sankar Guin Goutam Gangopadhyay Sujit Sarkhel Malay Kumar Ghoshal Asit Kumar Senapati Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia Annals of Indian Academy of Neurology Alzheimer disease behavioral and psychological symptoms of dementia neuropsychiatric inventory small vessel disease vascular dementia |
author_facet |
Tushar Kanti Bandyopadhyay Atanu Biswas Arijit Roy Deb Sankar Guin Goutam Gangopadhyay Sujit Sarkhel Malay Kumar Ghoshal Asit Kumar Senapati |
author_sort |
Tushar Kanti Bandyopadhyay |
title |
Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia |
title_short |
Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia |
title_full |
Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia |
title_fullStr |
Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia |
title_full_unstemmed |
Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia |
title_sort |
neuropsychiatric profiles in patients with alzheimer′s disease and vascular dementia |
publisher |
Wolters Kluwer Medknow Publications |
series |
Annals of Indian Academy of Neurology |
issn |
0972-2327 1998-3549 |
publishDate |
2014-01-01 |
description |
Background/Aims: The aim of the following study is to compare the behavioral and psychological symptoms of dementia (BPSD) in patients of Alzheimer disease (AD) and vascular dementia (VaD). Materials and Methods: We used National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer′s Disease and Related Disorders Association criteria for diagnosing AD and National Institute of Neurological Disorders and Stroke-Association International pour la Recherche et l′Enseignement en Neurosciences Criteria for diagnosing VaD. VaD cohort was further subcategorized into small vessel and large vessel disease. The severity of cognitive impairment and the BPSD were studied by means of the Clinical Dementia Rating Scale (CDR) and the Neuropsychiatric Inventory respectively. Results: We studied 50 AD and 50 VaD patients of whom 38 were small vessels and 12 were large vessels VaD. The severity of dementia was comparable in both groups. The agitation/aggression, depression/dysphoria, anxiety, apathy/indifference, irritability, aberrant motor behavior, appetite and eating behavior and night-time behaviors occurred significantly more frequently in patients with VaD than AD. We found a weak positive correlation between the CDR score and the number of neuropsychiatric symptoms per patient in both cohorts. Elation/euphoria, agitation/aggression was significantly more frequent in patients with large vessel in comparison to small vessel VaD. Conclusions: BPSD are common in both types of dementia and they are more severe in VaD than AD when the groups have similar levels of cognitive impairment. |
topic |
Alzheimer disease behavioral and psychological symptoms of dementia neuropsychiatric inventory small vessel disease vascular dementia |
url |
http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=3;spage=325;epage=330;aulast=Bandyopadhyay |
work_keys_str_mv |
AT tusharkantibandyopadhyay neuropsychiatricprofilesinpatientswithalzheimersdiseaseandvasculardementia AT atanubiswas neuropsychiatricprofilesinpatientswithalzheimersdiseaseandvasculardementia AT arijitroy neuropsychiatricprofilesinpatientswithalzheimersdiseaseandvasculardementia AT debsankarguin neuropsychiatricprofilesinpatientswithalzheimersdiseaseandvasculardementia AT goutamgangopadhyay neuropsychiatricprofilesinpatientswithalzheimersdiseaseandvasculardementia AT sujitsarkhel neuropsychiatricprofilesinpatientswithalzheimersdiseaseandvasculardementia AT malaykumarghoshal neuropsychiatricprofilesinpatientswithalzheimersdiseaseandvasculardementia AT asitkumarsenapati neuropsychiatricprofilesinpatientswithalzheimersdiseaseandvasculardementia |
_version_ |
1725568271440150528 |