Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia

Background/Aims: The aim of the following study is to compare the behavioral and psychological symptoms of dementia (BPSD) in patients of Alzheimer disease (AD) and vascular dementia (VaD). Materials and Methods: We used National Institute of Neurological and Communicative Disorders and Stroke-Alzhe...

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Main Authors: Tushar Kanti Bandyopadhyay, Atanu Biswas, Arijit Roy, Deb Sankar Guin, Goutam Gangopadhyay, Sujit Sarkhel, Malay Kumar Ghoshal, Asit Kumar Senapati
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Annals of Indian Academy of Neurology
Subjects:
Online Access:http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=3;spage=325;epage=330;aulast=Bandyopadhyay
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spelling doaj-7138750baea04cc7ad717f08bb3b989c2020-11-24T23:22:22ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492014-01-0117332533010.4103/0972-2327.138520Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementiaTushar Kanti BandyopadhyayAtanu BiswasArijit RoyDeb Sankar GuinGoutam GangopadhyaySujit SarkhelMalay Kumar GhoshalAsit Kumar SenapatiBackground/Aims: The aim of the following study is to compare the behavioral and psychological symptoms of dementia (BPSD) in patients of Alzheimer disease (AD) and vascular dementia (VaD). Materials and Methods: We used National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer′s Disease and Related Disorders Association criteria for diagnosing AD and National Institute of Neurological Disorders and Stroke-Association International pour la Recherche et l′Enseignement en Neurosciences Criteria for diagnosing VaD. VaD cohort was further subcategorized into small vessel and large vessel disease. The severity of cognitive impairment and the BPSD were studied by means of the Clinical Dementia Rating Scale (CDR) and the Neuropsychiatric Inventory respectively. Results: We studied 50 AD and 50 VaD patients of whom 38 were small vessels and 12 were large vessels VaD. The severity of dementia was comparable in both groups. The agitation/aggression, depression/dysphoria, anxiety, apathy/indifference, irritability, aberrant motor behavior, appetite and eating behavior and night-time behaviors occurred significantly more frequently in patients with VaD than AD. We found a weak positive correlation between the CDR score and the number of neuropsychiatric symptoms per patient in both cohorts. Elation/euphoria, agitation/aggression was significantly more frequent in patients with large vessel in comparison to small vessel VaD. Conclusions: BPSD are common in both types of dementia and they are more severe in VaD than AD when the groups have similar levels of cognitive impairment.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=3;spage=325;epage=330;aulast=BandyopadhyayAlzheimer diseasebehavioral and psychological symptoms of dementianeuropsychiatric inventorysmall vessel diseasevascular dementia
collection DOAJ
language English
format Article
sources DOAJ
author Tushar Kanti Bandyopadhyay
Atanu Biswas
Arijit Roy
Deb Sankar Guin
Goutam Gangopadhyay
Sujit Sarkhel
Malay Kumar Ghoshal
Asit Kumar Senapati
spellingShingle Tushar Kanti Bandyopadhyay
Atanu Biswas
Arijit Roy
Deb Sankar Guin
Goutam Gangopadhyay
Sujit Sarkhel
Malay Kumar Ghoshal
Asit Kumar Senapati
Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia
Annals of Indian Academy of Neurology
Alzheimer disease
behavioral and psychological symptoms of dementia
neuropsychiatric inventory
small vessel disease
vascular dementia
author_facet Tushar Kanti Bandyopadhyay
Atanu Biswas
Arijit Roy
Deb Sankar Guin
Goutam Gangopadhyay
Sujit Sarkhel
Malay Kumar Ghoshal
Asit Kumar Senapati
author_sort Tushar Kanti Bandyopadhyay
title Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia
title_short Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia
title_full Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia
title_fullStr Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia
title_full_unstemmed Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia
title_sort neuropsychiatric profiles in patients with alzheimer′s disease and vascular dementia
publisher Wolters Kluwer Medknow Publications
series Annals of Indian Academy of Neurology
issn 0972-2327
1998-3549
publishDate 2014-01-01
description Background/Aims: The aim of the following study is to compare the behavioral and psychological symptoms of dementia (BPSD) in patients of Alzheimer disease (AD) and vascular dementia (VaD). Materials and Methods: We used National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer′s Disease and Related Disorders Association criteria for diagnosing AD and National Institute of Neurological Disorders and Stroke-Association International pour la Recherche et l′Enseignement en Neurosciences Criteria for diagnosing VaD. VaD cohort was further subcategorized into small vessel and large vessel disease. The severity of cognitive impairment and the BPSD were studied by means of the Clinical Dementia Rating Scale (CDR) and the Neuropsychiatric Inventory respectively. Results: We studied 50 AD and 50 VaD patients of whom 38 were small vessels and 12 were large vessels VaD. The severity of dementia was comparable in both groups. The agitation/aggression, depression/dysphoria, anxiety, apathy/indifference, irritability, aberrant motor behavior, appetite and eating behavior and night-time behaviors occurred significantly more frequently in patients with VaD than AD. We found a weak positive correlation between the CDR score and the number of neuropsychiatric symptoms per patient in both cohorts. Elation/euphoria, agitation/aggression was significantly more frequent in patients with large vessel in comparison to small vessel VaD. Conclusions: BPSD are common in both types of dementia and they are more severe in VaD than AD when the groups have similar levels of cognitive impairment.
topic Alzheimer disease
behavioral and psychological symptoms of dementia
neuropsychiatric inventory
small vessel disease
vascular dementia
url http://www.annalsofian.org/article.asp?issn=0972-2327;year=2014;volume=17;issue=3;spage=325;epage=330;aulast=Bandyopadhyay
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