Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression
Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360–400 nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in t...
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2017-02-01
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doaj-7139060b87ca4ed6979cc720763b82072020-11-25T01:33:18ZengElsevierEBioMedicine2352-39642017-02-0115C21021910.1016/j.ebiom.2016.12.007Violet Light Exposure Can Be a Preventive Strategy Against Myopia ProgressionHidemasa Torii0Toshihide Kurihara1Yuko Seko2Kazuno Negishi3Kazuhiko Ohnuma4Takaaki Inaba5Motoko Kawashima6Xiaoyan Jiang7Shinichiro Kondo8Maki Miyauchi9Yukihiro Miwa10Yusaku Katada11Kiwako Mori12Keiichi Kato13Kinya Tsubota14Hiroshi Goto15Mayumi Oda16Megumi Hatori17Kazuo Tsubota18Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanVisual Functions Section, Department of Rehabilitation for Sensory Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, Tokorozawa-shi, Saitama 359-8555, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanCenter for Frontier Medical Engineering, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanKato Eye Center, 2-8-10, Yoshioka-higashi, Taiwa-cho, Kurokawa-gun, Miyagi 981-3627, JapanLaboratory of Photobiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanDepartment of Systems Medicine, The Mitsunada Sakaguchi Laboratory, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanPrevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360–400 nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in the chick myopia model. Expression microarray analyses revealed that myopia suppressive gene EGR1 was upregulated by VL exposure. VL exposure induced significantly higher upregulation of EGR1 in chick chorioretinal tissues than blue light under the same conditions. Next, we conducted clinical research retrospectively to compare the AL elongation among myopic children who wore eyeglasses (VL blocked) and two types of contact lenses (partially VL blocked and VL transmitting). The data showed the VL transmitting contact lenses suppressed myopia progression most. These results suggest that VL is one of the important outdoor environmental factors for myopia control. Since VL is apt to be excluded from our modern society due to the excessive UV protection, VL exposure can be a preventive strategy against myopia progression.http://www.sciencedirect.com/science/article/pii/S2352396416305862Violet lightUltraviolet lightOutdoorsMyopiaAxial lengthRefraction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hidemasa Torii Toshihide Kurihara Yuko Seko Kazuno Negishi Kazuhiko Ohnuma Takaaki Inaba Motoko Kawashima Xiaoyan Jiang Shinichiro Kondo Maki Miyauchi Yukihiro Miwa Yusaku Katada Kiwako Mori Keiichi Kato Kinya Tsubota Hiroshi Goto Mayumi Oda Megumi Hatori Kazuo Tsubota |
spellingShingle |
Hidemasa Torii Toshihide Kurihara Yuko Seko Kazuno Negishi Kazuhiko Ohnuma Takaaki Inaba Motoko Kawashima Xiaoyan Jiang Shinichiro Kondo Maki Miyauchi Yukihiro Miwa Yusaku Katada Kiwako Mori Keiichi Kato Kinya Tsubota Hiroshi Goto Mayumi Oda Megumi Hatori Kazuo Tsubota Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression EBioMedicine Violet light Ultraviolet light Outdoors Myopia Axial length Refraction |
author_facet |
Hidemasa Torii Toshihide Kurihara Yuko Seko Kazuno Negishi Kazuhiko Ohnuma Takaaki Inaba Motoko Kawashima Xiaoyan Jiang Shinichiro Kondo Maki Miyauchi Yukihiro Miwa Yusaku Katada Kiwako Mori Keiichi Kato Kinya Tsubota Hiroshi Goto Mayumi Oda Megumi Hatori Kazuo Tsubota |
author_sort |
Hidemasa Torii |
title |
Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression |
title_short |
Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression |
title_full |
Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression |
title_fullStr |
Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression |
title_full_unstemmed |
Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression |
title_sort |
violet light exposure can be a preventive strategy against myopia progression |
publisher |
Elsevier |
series |
EBioMedicine |
issn |
2352-3964 |
publishDate |
2017-02-01 |
description |
Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360–400 nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in the chick myopia model. Expression microarray analyses revealed that myopia suppressive gene EGR1 was upregulated by VL exposure. VL exposure induced significantly higher upregulation of EGR1 in chick chorioretinal tissues than blue light under the same conditions. Next, we conducted clinical research retrospectively to compare the AL elongation among myopic children who wore eyeglasses (VL blocked) and two types of contact lenses (partially VL blocked and VL transmitting). The data showed the VL transmitting contact lenses suppressed myopia progression most. These results suggest that VL is one of the important outdoor environmental factors for myopia control. Since VL is apt to be excluded from our modern society due to the excessive UV protection, VL exposure can be a preventive strategy against myopia progression. |
topic |
Violet light Ultraviolet light Outdoors Myopia Axial length Refraction |
url |
http://www.sciencedirect.com/science/article/pii/S2352396416305862 |
work_keys_str_mv |
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