Effects of transcranial direct current stimulation on temperature and pain perception
Abstract Transcranial direct current stimulation modifies cortical excitability and in consequence some cerebral functions. In the present study we aimed to elucidate whether tDCS could affect temperature and pain perceptions in healthy subjects testing different stimulation parameters. A total of 2...
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2017-06-01
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doaj-713d311dc92b44a6a3362ca770ae44da2020-12-08T00:10:10ZengNature Publishing GroupScientific Reports2045-23222017-06-01711910.1038/s41598-017-03173-2Effects of transcranial direct current stimulation on temperature and pain perceptionLaura Mordillo-Mateos0Michele Dileone1Vanesa Soto-León2Angela Brocalero-Camacho3Yolanda A Pérez-Borrego4Ana Onate-Figuerez5Juan Aguilar6Antonio Oliviero7FENNSI Group, Hospital Nacional de Parapléjicos, SESCAMCentro Integral de Neurociencias, HM Hospital Puerta del SurFENNSI Group, Hospital Nacional de Parapléjicos, SESCAMFENNSI Group, Hospital Nacional de Parapléjicos, SESCAMFENNSI Group, Hospital Nacional de Parapléjicos, SESCAMFENNSI Group, Hospital Nacional de Parapléjicos, SESCAMExperimental Neurophysiology Group, Hospital Nacional de Parapléjicos, SESCAMFENNSI Group, Hospital Nacional de Parapléjicos, SESCAMAbstract Transcranial direct current stimulation modifies cortical excitability and in consequence some cerebral functions. In the present study we aimed to elucidate whether tDCS could affect temperature and pain perceptions in healthy subjects testing different stimulation parameters. A total of 20 healthy subjects were studied by means of quantitative sensory testing. Two different experiments were performed. First, we studied the effects of 15 minutes 2 mA anodal transcranial direct current stimulation applied over left M1 and parietal cortex in two separated sessions. Then, we tested the effects of 5 minutes tDCS over M1 by means of a sham controlled design to optimize the possibility to study minimal effects of tDCS using different polarities (cathodal and anodal) and intensities (1 and 2 mA). 2 mA anodal tDCS, when applied for both 15 and 5 minutes over the motor cortex, increased cold perception threshold. Conversely, motor cortex cathodal tDCS modulated cold perception threshold only when 1 mA intensity was used. M1-tDCS can modify the temperature perception; these effects are polarity and intensity dependent. As stimulation intensity seems critical to determine the effects, we suggest that for clinical application strong anodal tDCS (>1 mA) or weak cathodal tDCS (<2 mA) should be used for pain control.https://doi.org/10.1038/s41598-017-03173-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura Mordillo-Mateos Michele Dileone Vanesa Soto-León Angela Brocalero-Camacho Yolanda A Pérez-Borrego Ana Onate-Figuerez Juan Aguilar Antonio Oliviero |
spellingShingle |
Laura Mordillo-Mateos Michele Dileone Vanesa Soto-León Angela Brocalero-Camacho Yolanda A Pérez-Borrego Ana Onate-Figuerez Juan Aguilar Antonio Oliviero Effects of transcranial direct current stimulation on temperature and pain perception Scientific Reports |
author_facet |
Laura Mordillo-Mateos Michele Dileone Vanesa Soto-León Angela Brocalero-Camacho Yolanda A Pérez-Borrego Ana Onate-Figuerez Juan Aguilar Antonio Oliviero |
author_sort |
Laura Mordillo-Mateos |
title |
Effects of transcranial direct current stimulation on temperature and pain perception |
title_short |
Effects of transcranial direct current stimulation on temperature and pain perception |
title_full |
Effects of transcranial direct current stimulation on temperature and pain perception |
title_fullStr |
Effects of transcranial direct current stimulation on temperature and pain perception |
title_full_unstemmed |
Effects of transcranial direct current stimulation on temperature and pain perception |
title_sort |
effects of transcranial direct current stimulation on temperature and pain perception |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-06-01 |
description |
Abstract Transcranial direct current stimulation modifies cortical excitability and in consequence some cerebral functions. In the present study we aimed to elucidate whether tDCS could affect temperature and pain perceptions in healthy subjects testing different stimulation parameters. A total of 20 healthy subjects were studied by means of quantitative sensory testing. Two different experiments were performed. First, we studied the effects of 15 minutes 2 mA anodal transcranial direct current stimulation applied over left M1 and parietal cortex in two separated sessions. Then, we tested the effects of 5 minutes tDCS over M1 by means of a sham controlled design to optimize the possibility to study minimal effects of tDCS using different polarities (cathodal and anodal) and intensities (1 and 2 mA). 2 mA anodal tDCS, when applied for both 15 and 5 minutes over the motor cortex, increased cold perception threshold. Conversely, motor cortex cathodal tDCS modulated cold perception threshold only when 1 mA intensity was used. M1-tDCS can modify the temperature perception; these effects are polarity and intensity dependent. As stimulation intensity seems critical to determine the effects, we suggest that for clinical application strong anodal tDCS (>1 mA) or weak cathodal tDCS (<2 mA) should be used for pain control. |
url |
https://doi.org/10.1038/s41598-017-03173-2 |
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