MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery

MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery

The lack of a unifying metric characterizing combinatorial drug interactions has impeded the development of combinatorial therapies. Here, the authors present MuSyC, a consensus synergy metric that overcomes several caveats associated with other, popular metrics.

Bibliographic Details
Main Authors: David J. Wooten, Christian T. Meyer, Alexander L. R. Lubbock, Vito Quaranta, Carlos F. Lopez
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24789-z
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spelling doaj-714bcb94521f45b18fccb436c738bfea2021-08-01T11:38:39ZengNature Publishing GroupNature Communications2041-17232021-07-0112111610.1038/s41467-021-24789-zMuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discoveryDavid J. Wooten0Christian T. Meyer1Alexander L. R. Lubbock2Vito Quaranta3Carlos F. Lopez4Department of Physics, Pennsylvania State UniversityProgram in Chemical and Physical Biology, Vanderbilt University School of MedicineDepartment of Biochemistry, Vanderbilt University NashvilleDepartment of Biochemistry, Vanderbilt University NashvilleDepartment of Biochemistry, Vanderbilt University NashvilleThe lack of a unifying metric characterizing combinatorial drug interactions has impeded the development of combinatorial therapies. Here, the authors present MuSyC, a consensus synergy metric that overcomes several caveats associated with other, popular metrics.https://doi.org/10.1038/s41467-021-24789-z
collection DOAJ
language English
format Article
sources DOAJ
author David J. Wooten
Christian T. Meyer
Alexander L. R. Lubbock
Vito Quaranta
Carlos F. Lopez
spellingShingle David J. Wooten
Christian T. Meyer
Alexander L. R. Lubbock
Vito Quaranta
Carlos F. Lopez
MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery
Nature Communications
author_facet David J. Wooten
Christian T. Meyer
Alexander L. R. Lubbock
Vito Quaranta
Carlos F. Lopez
author_sort David J. Wooten
title MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery
title_short MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery
title_full MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery
title_fullStr MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery
title_full_unstemmed MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery
title_sort musyc is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description The lack of a unifying metric characterizing combinatorial drug interactions has impeded the development of combinatorial therapies. Here, the authors present MuSyC, a consensus synergy metric that overcomes several caveats associated with other, popular metrics.
url https://doi.org/10.1038/s41467-021-24789-z
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AT vitoquaranta musycisaconsensusframeworkthatunifiesmultidrugsynergymetricsforcombinatorialdrugdiscovery
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