Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction.
Lipid metabolites are indispensable regulators of physiological and pathological processes, including atherosclerosis and coronary artery disease (CAD). However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood. We perfo...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4530944?pdf=render |
id |
doaj-7150c171707c4a8aa9310f3c9b3f27bf |
---|---|
record_format |
Article |
spelling |
doaj-7150c171707c4a8aa9310f3c9b3f27bf2020-11-25T01:51:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01108e013522810.1371/journal.pone.0135228Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction.Ju Yeon ParkSang-Hak LeeMin-Jeong ShinGeum-Sook HwangLipid metabolites are indispensable regulators of physiological and pathological processes, including atherosclerosis and coronary artery disease (CAD). However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood. We performed lipid profiling to identify alterations in lipid metabolism in patients with angina and myocardial infarction (MI). Global lipid profiling was applied to serum samples from patients with CAD (angina and MI) and age-, sex-, and body mass index-matched healthy subjects using ultra-performance liquid chromatography/quadruple time-of-flight mass spectrometry and multivariate statistical analysis. A multivariate analysis showed a clear separation between the patients with CAD and normal controls. Lysophosphatidylcholine (lysoPC) and lysophosphatidylethanolamine (lysoPE) species containing unsaturated fatty acids and free fatty acids were associated with an increased risk of CAD, whereas species of lysoPC and lyso-alkyl PC containing saturated fatty acids were associated with a decreased risk. Additionally, PC species containing palmitic acid, diacylglycerol, sphingomyelin, and ceramide were associated with an increased risk of MI, whereas PE-plasmalogen and phosphatidylinositol species were associated with a decreased risk. In MI patients, we found strong positive correlation between lipid metabolites related to the sphingolipid pathway, sphingomyelin, and ceramide and acute inflammatory markers (high-sensitivity C-reactive protein). The results of this study demonstrate altered signatures in lipid metabolism in patients with angina or MI. Lipidomic profiling could provide the information to identity the specific lipid metabolites under the presence of disturbed metabolic pathways in patients with CAD.http://europepmc.org/articles/PMC4530944?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ju Yeon Park Sang-Hak Lee Min-Jeong Shin Geum-Sook Hwang |
spellingShingle |
Ju Yeon Park Sang-Hak Lee Min-Jeong Shin Geum-Sook Hwang Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. PLoS ONE |
author_facet |
Ju Yeon Park Sang-Hak Lee Min-Jeong Shin Geum-Sook Hwang |
author_sort |
Ju Yeon Park |
title |
Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. |
title_short |
Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. |
title_full |
Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. |
title_fullStr |
Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. |
title_full_unstemmed |
Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. |
title_sort |
alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
Lipid metabolites are indispensable regulators of physiological and pathological processes, including atherosclerosis and coronary artery disease (CAD). However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood. We performed lipid profiling to identify alterations in lipid metabolism in patients with angina and myocardial infarction (MI). Global lipid profiling was applied to serum samples from patients with CAD (angina and MI) and age-, sex-, and body mass index-matched healthy subjects using ultra-performance liquid chromatography/quadruple time-of-flight mass spectrometry and multivariate statistical analysis. A multivariate analysis showed a clear separation between the patients with CAD and normal controls. Lysophosphatidylcholine (lysoPC) and lysophosphatidylethanolamine (lysoPE) species containing unsaturated fatty acids and free fatty acids were associated with an increased risk of CAD, whereas species of lysoPC and lyso-alkyl PC containing saturated fatty acids were associated with a decreased risk. Additionally, PC species containing palmitic acid, diacylglycerol, sphingomyelin, and ceramide were associated with an increased risk of MI, whereas PE-plasmalogen and phosphatidylinositol species were associated with a decreased risk. In MI patients, we found strong positive correlation between lipid metabolites related to the sphingolipid pathway, sphingomyelin, and ceramide and acute inflammatory markers (high-sensitivity C-reactive protein). The results of this study demonstrate altered signatures in lipid metabolism in patients with angina or MI. Lipidomic profiling could provide the information to identity the specific lipid metabolites under the presence of disturbed metabolic pathways in patients with CAD. |
url |
http://europepmc.org/articles/PMC4530944?pdf=render |
work_keys_str_mv |
AT juyeonpark alterationinmetabolicsignatureandlipidmetabolisminpatientswithanginapectorisandmyocardialinfarction AT sanghaklee alterationinmetabolicsignatureandlipidmetabolisminpatientswithanginapectorisandmyocardialinfarction AT minjeongshin alterationinmetabolicsignatureandlipidmetabolisminpatientswithanginapectorisandmyocardialinfarction AT geumsookhwang alterationinmetabolicsignatureandlipidmetabolisminpatientswithanginapectorisandmyocardialinfarction |
_version_ |
1724997836843515904 |